MAP4K4-REV1 Fusion FISH Probe
The MAP4K4-REV1 Fusion FISH Probe is used to confirm a fusion of the MAP4K4 and REV1 genes. The fusion of the MAP4K4 and REV1 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAP4K4-REV1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAP4K4-REV1-20-RERE | 20 (40 μL) | 200 μL |
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| MAP4K4-REV1-20-REOR | 20 (40 μL) | 200 μL |
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| MAP4K4-REV1-20-REGO | 20 (40 μL) | 200 μL |
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| MAP4K4-REV1-20-REGR | 20 (40 μL) | 200 μL |
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| MAP4K4-REV1-20-REAQ | 20 (40 μL) | 200 μL |
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| MAP4K4-REV1-20-ORRE | 20 (40 μL) | 200 μL |
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| MAP4K4-REV1-20-OROR | 20 (40 μL) | 200 μL |
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| MAP4K4-REV1-20-ORGO | 20 (40 μL) | 200 μL |
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| MAP4K4-REV1-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAP4K4-REV1-20-GORE | 20 (40 μL) | 200 μL |
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| MAP4K4-REV1-20-GOOR | 20 (40 μL) | 200 μL |
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| MAP4K4-REV1-20-GOGO | 20 (40 μL) | 200 μL |
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| MAP4K4-REV1-20-GOGR | 20 (40 μL) | 200 μL |
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| MAP4K4-REV1-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAP4K4-REV1-20-GRRE | 20 (40 μL) | 200 μL |
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| MAP4K4-REV1-20-GROR | 20 (40 μL) | 200 μL |
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| MAP4K4-REV1-20-GRGO | 20 (40 μL) | 200 μL |
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| MAP4K4-REV1-20-GRGR | 20 (40 μL) | 200 μL |
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| MAP4K4-REV1-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAP4K4-REV1-20-AQRE | 20 (40 μL) | 200 μL |
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| MAP4K4-REV1-20-AQOR | 20 (40 μL) | 200 μL |
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| MAP4K4-REV1-20-AQGO | 20 (40 μL) | 200 μL |
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| MAP4K4-REV1-20-AQGR | 20 (40 μL) | 200 μL |
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| MAP4K4-REV1-20-AQAQ | 20 (40 μL) | 200 μL |
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MAP4K4 Gene Summary
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Mitogen-activated Protein Kinase Kinase Kinase Kinase 4
Chromosome: CHR2: 102314164 -102511152
Locus: 2q11.2
REV1 Gene Summary
This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. [provided by RefSeq, Mar 2016]
Gene Name: REV1, DNA Directed Polymerase
Chromosome: CHR2: 100016937 -100106480
Locus: 2q11.2
Gene Diseases
The MAP4K4 REV1 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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