MAP4-SPINK8 Fusion FISH Probe
The MAP4-SPINK8 Fusion FISH Probe is used to confirm a fusion of the MAP4 and SPINK8 genes. The fusion of the MAP4 and SPINK8 genes has been associated with Bladder Urothelial Carcinoma, Lung Adenocarcinoma, Lung Adenocarcinoma, Uterine Corpus Endometrial Carcinoma, Uterine Corpus Endometrial Carcinoma, and Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAP4-SPINK8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAP4-SPINK8-20-RERE | 20 (40 μL) | 200 μL |
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| MAP4-SPINK8-20-REOR | 20 (40 μL) | 200 μL |
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| MAP4-SPINK8-20-REGO | 20 (40 μL) | 200 μL |
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| MAP4-SPINK8-20-REGR | 20 (40 μL) | 200 μL |
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| MAP4-SPINK8-20-REAQ | 20 (40 μL) | 200 μL |
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| MAP4-SPINK8-20-ORRE | 20 (40 μL) | 200 μL |
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| MAP4-SPINK8-20-OROR | 20 (40 μL) | 200 μL |
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| MAP4-SPINK8-20-ORGO | 20 (40 μL) | 200 μL |
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| MAP4-SPINK8-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAP4-SPINK8-20-GORE | 20 (40 μL) | 200 μL |
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| MAP4-SPINK8-20-GOOR | 20 (40 μL) | 200 μL |
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| MAP4-SPINK8-20-GOGO | 20 (40 μL) | 200 μL |
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| MAP4-SPINK8-20-GOGR | 20 (40 μL) | 200 μL |
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| MAP4-SPINK8-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAP4-SPINK8-20-GRRE | 20 (40 μL) | 200 μL |
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| MAP4-SPINK8-20-GROR | 20 (40 μL) | 200 μL |
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| MAP4-SPINK8-20-GRGO | 20 (40 μL) | 200 μL |
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| MAP4-SPINK8-20-GRGR | 20 (40 μL) | 200 μL |
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| MAP4-SPINK8-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAP4-SPINK8-20-AQRE | 20 (40 μL) | 200 μL |
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| MAP4-SPINK8-20-AQOR | 20 (40 μL) | 200 μL |
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| MAP4-SPINK8-20-AQGO | 20 (40 μL) | 200 μL |
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| MAP4-SPINK8-20-AQGR | 20 (40 μL) | 200 μL |
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| MAP4-SPINK8-20-AQAQ | 20 (40 μL) | 200 μL |
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MAP4 Gene Summary
The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Name: Microtubule Associated Protein 4
Chromosome: CHR3: 47892179 -48130769
Locus: 3p21.31
SPINK8 Gene Summary
The Serine Peptidase Inhibitor, Kazal Type 8 (putative) (SPINK8) gene is located on chr3 :48348335-48369831 at 3p21.31.
Gene Name: Serine Peptidase Inhibitor, Kazal Type 8 (putative)
Chromosome: CHR3: 48348335 -48369831
Locus: 3p21.31
Gene Diseases
The MAP4 SPINK8 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
| Lung Adenocarcinoma |
| Lung Adenocarcinoma |
| Uterine Corpus Endometrial Carcinoma |
| Uterine Corpus Endometrial Carcinoma |
| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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