MAP4-NME6 Fusion FISH Probe
The MAP4-NME6 Fusion FISH Probe is used to confirm a fusion of the MAP4 and NME6 genes. The fusion of the MAP4 and NME6 genes has been associated with Testicular Germ Cell Tumors, and Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAP4-NME6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAP4-NME6-20-RERE | 20 (40 μL) | 200 μL |
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| MAP4-NME6-20-REOR | 20 (40 μL) | 200 μL |
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| MAP4-NME6-20-REGO | 20 (40 μL) | 200 μL |
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| MAP4-NME6-20-REGR | 20 (40 μL) | 200 μL |
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| MAP4-NME6-20-REAQ | 20 (40 μL) | 200 μL |
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| MAP4-NME6-20-ORRE | 20 (40 μL) | 200 μL |
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| MAP4-NME6-20-OROR | 20 (40 μL) | 200 μL |
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| MAP4-NME6-20-ORGO | 20 (40 μL) | 200 μL |
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| MAP4-NME6-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAP4-NME6-20-GORE | 20 (40 μL) | 200 μL |
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| MAP4-NME6-20-GOOR | 20 (40 μL) | 200 μL |
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| MAP4-NME6-20-GOGO | 20 (40 μL) | 200 μL |
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| MAP4-NME6-20-GOGR | 20 (40 μL) | 200 μL |
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| MAP4-NME6-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAP4-NME6-20-GRRE | 20 (40 μL) | 200 μL |
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| MAP4-NME6-20-GROR | 20 (40 μL) | 200 μL |
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| MAP4-NME6-20-GRGO | 20 (40 μL) | 200 μL |
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| MAP4-NME6-20-GRGR | 20 (40 μL) | 200 μL |
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| MAP4-NME6-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAP4-NME6-20-AQRE | 20 (40 μL) | 200 μL |
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| MAP4-NME6-20-AQOR | 20 (40 μL) | 200 μL |
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| MAP4-NME6-20-AQGO | 20 (40 μL) | 200 μL |
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| MAP4-NME6-20-AQGR | 20 (40 μL) | 200 μL |
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| MAP4-NME6-20-AQAQ | 20 (40 μL) | 200 μL |
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MAP4 Gene Summary
The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Name: Microtubule Associated Protein 4
Chromosome: CHR3: 47892179 -48130769
Locus: 3p21.31
NME6 Gene Summary
Nucleoside diphosphate (NDP) kinases (EC 2.7.4.6), such as NME6, are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates (Mehus et al., 1999 [PubMed 10453732]).[supplied by OMIM, Jul 2010]
Gene Name: NME/NM23 Nucleoside Diphosphate Kinase 6
Chromosome: CHR3: 48335588 -48342848
Locus: 3p21.31
Gene Diseases
The MAP4 NME6 Fusion has been associated with the following diseases:
| Disease Name |
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| Testicular Germ Cell Tumors |
| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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