MAP3K5-OSTM1 Fusion FISH Probe
The MAP3K5-OSTM1 Fusion FISH Probe is used to confirm a fusion of the MAP3K5 and OSTM1 genes. The fusion of the MAP3K5 and OSTM1 genes has been associated with Uveal Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAP3K5-OSTM1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAP3K5-OSTM1-20-RERE | 20 (40 μL) | 200 μL |
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| MAP3K5-OSTM1-20-REOR | 20 (40 μL) | 200 μL |
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| MAP3K5-OSTM1-20-REGO | 20 (40 μL) | 200 μL |
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| MAP3K5-OSTM1-20-REGR | 20 (40 μL) | 200 μL |
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| MAP3K5-OSTM1-20-REAQ | 20 (40 μL) | 200 μL |
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| MAP3K5-OSTM1-20-ORRE | 20 (40 μL) | 200 μL |
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| MAP3K5-OSTM1-20-OROR | 20 (40 μL) | 200 μL |
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| MAP3K5-OSTM1-20-ORGO | 20 (40 μL) | 200 μL |
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| MAP3K5-OSTM1-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAP3K5-OSTM1-20-GORE | 20 (40 μL) | 200 μL |
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| MAP3K5-OSTM1-20-GOOR | 20 (40 μL) | 200 μL |
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| MAP3K5-OSTM1-20-GOGO | 20 (40 μL) | 200 μL |
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| MAP3K5-OSTM1-20-GOGR | 20 (40 μL) | 200 μL |
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| MAP3K5-OSTM1-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAP3K5-OSTM1-20-GRRE | 20 (40 μL) | 200 μL |
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| MAP3K5-OSTM1-20-GROR | 20 (40 μL) | 200 μL |
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| MAP3K5-OSTM1-20-GRGO | 20 (40 μL) | 200 μL |
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| MAP3K5-OSTM1-20-GRGR | 20 (40 μL) | 200 μL |
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| MAP3K5-OSTM1-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAP3K5-OSTM1-20-AQRE | 20 (40 μL) | 200 μL |
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| MAP3K5-OSTM1-20-AQOR | 20 (40 μL) | 200 μL |
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| MAP3K5-OSTM1-20-AQGO | 20 (40 μL) | 200 μL |
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| MAP3K5-OSTM1-20-AQGR | 20 (40 μL) | 200 μL |
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| MAP3K5-OSTM1-20-AQAQ | 20 (40 μL) | 200 μL |
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MAP3K5 Gene Summary
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008]
Gene Name: Mitogen-activated Protein Kinase Kinase Kinase 5
Chromosome: CHR6: 136878186 -137113656
Locus: 6q23.3
OSTM1 Gene Summary
This gene encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis. [provided by RefSeq, Jul 2008]
Gene Name: Osteopetrosis Associated Transmembrane Protein 1
Chromosome: CHR6: 108362612 -108395941
Locus: 6q21
Gene Diseases
The MAP3K5 OSTM1 Fusion has been associated with the following diseases:
| Disease Name |
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| Uveal Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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