MAP3K5-ARFIP1 Fusion FISH Probe
The MAP3K5-ARFIP1 Fusion FISH Probe is used to confirm a fusion of the MAP3K5 and ARFIP1 genes. The fusion of the MAP3K5 and ARFIP1 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAP3K5-ARFIP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAP3K5-ARFIP1-20-RERE | 20 (40 μL) | 200 μL |
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| MAP3K5-ARFIP1-20-REOR | 20 (40 μL) | 200 μL |
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| MAP3K5-ARFIP1-20-REGO | 20 (40 μL) | 200 μL |
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| MAP3K5-ARFIP1-20-REGR | 20 (40 μL) | 200 μL |
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| MAP3K5-ARFIP1-20-REAQ | 20 (40 μL) | 200 μL |
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| MAP3K5-ARFIP1-20-ORRE | 20 (40 μL) | 200 μL |
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| MAP3K5-ARFIP1-20-OROR | 20 (40 μL) | 200 μL |
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| MAP3K5-ARFIP1-20-ORGO | 20 (40 μL) | 200 μL |
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| MAP3K5-ARFIP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAP3K5-ARFIP1-20-GORE | 20 (40 μL) | 200 μL |
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| MAP3K5-ARFIP1-20-GOOR | 20 (40 μL) | 200 μL |
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| MAP3K5-ARFIP1-20-GOGO | 20 (40 μL) | 200 μL |
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| MAP3K5-ARFIP1-20-GOGR | 20 (40 μL) | 200 μL |
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| MAP3K5-ARFIP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAP3K5-ARFIP1-20-GRRE | 20 (40 μL) | 200 μL |
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| MAP3K5-ARFIP1-20-GROR | 20 (40 μL) | 200 μL |
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| MAP3K5-ARFIP1-20-GRGO | 20 (40 μL) | 200 μL |
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| MAP3K5-ARFIP1-20-GRGR | 20 (40 μL) | 200 μL |
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| MAP3K5-ARFIP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAP3K5-ARFIP1-20-AQRE | 20 (40 μL) | 200 μL |
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| MAP3K5-ARFIP1-20-AQOR | 20 (40 μL) | 200 μL |
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| MAP3K5-ARFIP1-20-AQGO | 20 (40 μL) | 200 μL |
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| MAP3K5-ARFIP1-20-AQGR | 20 (40 μL) | 200 μL |
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| MAP3K5-ARFIP1-20-AQAQ | 20 (40 μL) | 200 μL |
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MAP3K5 Gene Summary
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008]
Gene Name: Mitogen-activated Protein Kinase Kinase Kinase 5
Chromosome: CHR6: 136878186 -137113656
Locus: 6q23.3
ARFIP1 Gene Summary
The ADP Ribosylation Factor Interacting Protein 1 (ARFIP1) gene is located on chr4 :153701111-153833063 at 4q31.3.
Gene Name: ADP Ribosylation Factor Interacting Protein 1
Chromosome: CHR4: 153701111 -153833063
Locus: 4q31.3
Gene Diseases
The MAP3K5 ARFIP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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