MAP3K4-XAF1 Fusion FISH Probe
The MAP3K4-XAF1 Fusion FISH Probe is used to confirm a fusion of the MAP3K4 and XAF1 genes. The fusion of the MAP3K4 and XAF1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAP3K4-XAF1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAP3K4-XAF1-20-RERE | 20 (40 μL) | 200 μL |
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| MAP3K4-XAF1-20-REOR | 20 (40 μL) | 200 μL |
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| MAP3K4-XAF1-20-REGO | 20 (40 μL) | 200 μL |
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| MAP3K4-XAF1-20-REGR | 20 (40 μL) | 200 μL |
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| MAP3K4-XAF1-20-REAQ | 20 (40 μL) | 200 μL |
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| MAP3K4-XAF1-20-ORRE | 20 (40 μL) | 200 μL |
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| MAP3K4-XAF1-20-OROR | 20 (40 μL) | 200 μL |
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| MAP3K4-XAF1-20-ORGO | 20 (40 μL) | 200 μL |
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| MAP3K4-XAF1-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAP3K4-XAF1-20-GORE | 20 (40 μL) | 200 μL |
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| MAP3K4-XAF1-20-GOOR | 20 (40 μL) | 200 μL |
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| MAP3K4-XAF1-20-GOGO | 20 (40 μL) | 200 μL |
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| MAP3K4-XAF1-20-GOGR | 20 (40 μL) | 200 μL |
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| MAP3K4-XAF1-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAP3K4-XAF1-20-GRRE | 20 (40 μL) | 200 μL |
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| MAP3K4-XAF1-20-GROR | 20 (40 μL) | 200 μL |
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| MAP3K4-XAF1-20-GRGO | 20 (40 μL) | 200 μL |
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| MAP3K4-XAF1-20-GRGR | 20 (40 μL) | 200 μL |
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| MAP3K4-XAF1-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAP3K4-XAF1-20-AQRE | 20 (40 μL) | 200 μL |
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| MAP3K4-XAF1-20-AQOR | 20 (40 μL) | 200 μL |
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| MAP3K4-XAF1-20-AQGO | 20 (40 μL) | 200 μL |
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| MAP3K4-XAF1-20-AQGR | 20 (40 μL) | 200 μL |
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| MAP3K4-XAF1-20-AQAQ | 20 (40 μL) | 200 μL |
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MAP3K4 Gene Summary
The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Several alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, May 2014]
Gene Name: Mitogen-activated Protein Kinase Kinase Kinase 4
Chromosome: CHR6: 161412821 -161538417
Locus: 6q26
XAF1 Gene Summary
This gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and proteins which interfere with their activity, such as the encoded protein, affect the progress of the apoptosis signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Gene Name: XIAP Associated Factor 1
Chromosome: CHR17: 6659155 -6678964
Locus: 17p13.1
Gene Diseases
The MAP3K4 XAF1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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