MAP3K2-SHANK2 Fusion FISH Probe
The MAP3K2-SHANK2 Fusion FISH Probe is used to confirm a fusion of the MAP3K2 and SHANK2 genes. The fusion of the MAP3K2 and SHANK2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAP3K2-SHANK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAP3K2-SHANK2-20-RERE | 20 (40 μL) | 200 μL |
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| MAP3K2-SHANK2-20-REOR | 20 (40 μL) | 200 μL |
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| MAP3K2-SHANK2-20-REGO | 20 (40 μL) | 200 μL |
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| MAP3K2-SHANK2-20-REGR | 20 (40 μL) | 200 μL |
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| MAP3K2-SHANK2-20-REAQ | 20 (40 μL) | 200 μL |
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| MAP3K2-SHANK2-20-ORRE | 20 (40 μL) | 200 μL |
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| MAP3K2-SHANK2-20-OROR | 20 (40 μL) | 200 μL |
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| MAP3K2-SHANK2-20-ORGO | 20 (40 μL) | 200 μL |
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| MAP3K2-SHANK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAP3K2-SHANK2-20-GORE | 20 (40 μL) | 200 μL |
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| MAP3K2-SHANK2-20-GOOR | 20 (40 μL) | 200 μL |
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| MAP3K2-SHANK2-20-GOGO | 20 (40 μL) | 200 μL |
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| MAP3K2-SHANK2-20-GOGR | 20 (40 μL) | 200 μL |
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| MAP3K2-SHANK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAP3K2-SHANK2-20-GRRE | 20 (40 μL) | 200 μL |
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| MAP3K2-SHANK2-20-GROR | 20 (40 μL) | 200 μL |
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| MAP3K2-SHANK2-20-GRGO | 20 (40 μL) | 200 μL |
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| MAP3K2-SHANK2-20-GRGR | 20 (40 μL) | 200 μL |
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| MAP3K2-SHANK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAP3K2-SHANK2-20-AQRE | 20 (40 μL) | 200 μL |
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| MAP3K2-SHANK2-20-AQOR | 20 (40 μL) | 200 μL |
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| MAP3K2-SHANK2-20-AQGO | 20 (40 μL) | 200 μL |
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| MAP3K2-SHANK2-20-AQGR | 20 (40 μL) | 200 μL |
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| MAP3K2-SHANK2-20-AQAQ | 20 (40 μL) | 200 μL |
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MAP3K2 Gene Summary
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]
Gene Name: Mitogen-activated Protein Kinase Kinase Kinase 2
Chromosome: CHR2: 128056244 -128100805
Locus: 2q14.3
SHANK2 Gene Summary
This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Gene Name: SH3 And Multiple Ankyrin Repeat Domains 2
Chromosome: CHR11: 70313960 -70935808
Locus: 11q13.3-q13.4
Gene Diseases
The MAP3K2 SHANK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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