MAP3K14-SRP68 Fusion FISH Probe
The MAP3K14-SRP68 Fusion FISH Probe is used to confirm a fusion of the MAP3K14 and SRP68 genes. The fusion of the MAP3K14 and SRP68 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAP3K14-SRP68-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAP3K14-SRP68-20-RERE | 20 (40 μL) | 200 μL |
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| MAP3K14-SRP68-20-REOR | 20 (40 μL) | 200 μL |
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| MAP3K14-SRP68-20-REGO | 20 (40 μL) | 200 μL |
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| MAP3K14-SRP68-20-REGR | 20 (40 μL) | 200 μL |
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| MAP3K14-SRP68-20-REAQ | 20 (40 μL) | 200 μL |
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| MAP3K14-SRP68-20-ORRE | 20 (40 μL) | 200 μL |
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| MAP3K14-SRP68-20-OROR | 20 (40 μL) | 200 μL |
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| MAP3K14-SRP68-20-ORGO | 20 (40 μL) | 200 μL |
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| MAP3K14-SRP68-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAP3K14-SRP68-20-GORE | 20 (40 μL) | 200 μL |
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| MAP3K14-SRP68-20-GOOR | 20 (40 μL) | 200 μL |
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| MAP3K14-SRP68-20-GOGO | 20 (40 μL) | 200 μL |
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| MAP3K14-SRP68-20-GOGR | 20 (40 μL) | 200 μL |
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| MAP3K14-SRP68-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAP3K14-SRP68-20-GRRE | 20 (40 μL) | 200 μL |
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| MAP3K14-SRP68-20-GROR | 20 (40 μL) | 200 μL |
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| MAP3K14-SRP68-20-GRGO | 20 (40 μL) | 200 μL |
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| MAP3K14-SRP68-20-GRGR | 20 (40 μL) | 200 μL |
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| MAP3K14-SRP68-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAP3K14-SRP68-20-AQRE | 20 (40 μL) | 200 μL |
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| MAP3K14-SRP68-20-AQOR | 20 (40 μL) | 200 μL |
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| MAP3K14-SRP68-20-AQGO | 20 (40 μL) | 200 μL |
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| MAP3K14-SRP68-20-AQGR | 20 (40 μL) | 200 μL |
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| MAP3K14-SRP68-20-AQAQ | 20 (40 μL) | 200 μL |
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SRP68 Gene Summary
This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for SRP function. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and three pseudogenes of this gene are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, May 2012]
Gene Name: Signal Recognition Particle 68
Chromosome: CHR17: 74035190 -74068607
Locus: 17q25.1
MAP3K14 Gene Summary
This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]
Gene Name: Mitogen-activated Protein Kinase Kinase Kinase 14
Chromosome: CHR17: 43340487 -43394414
Locus: 17q21.31
Gene Diseases
The MAP3K14 SRP68 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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