MAP3K1-PARN Fusion FISH Probe
The MAP3K1-PARN Fusion FISH Probe is used to confirm a fusion of the MAP3K1 and PARN genes. The fusion of the MAP3K1 and PARN genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAP3K1-PARN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAP3K1-PARN-20-RERE | 20 (40 μL) | 200 μL |
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| MAP3K1-PARN-20-REOR | 20 (40 μL) | 200 μL |
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| MAP3K1-PARN-20-REGO | 20 (40 μL) | 200 μL |
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| MAP3K1-PARN-20-REGR | 20 (40 μL) | 200 μL |
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| MAP3K1-PARN-20-REAQ | 20 (40 μL) | 200 μL |
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| MAP3K1-PARN-20-ORRE | 20 (40 μL) | 200 μL |
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| MAP3K1-PARN-20-OROR | 20 (40 μL) | 200 μL |
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| MAP3K1-PARN-20-ORGO | 20 (40 μL) | 200 μL |
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| MAP3K1-PARN-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAP3K1-PARN-20-GORE | 20 (40 μL) | 200 μL |
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| MAP3K1-PARN-20-GOOR | 20 (40 μL) | 200 μL |
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| MAP3K1-PARN-20-GOGO | 20 (40 μL) | 200 μL |
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| MAP3K1-PARN-20-GOGR | 20 (40 μL) | 200 μL |
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| MAP3K1-PARN-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAP3K1-PARN-20-GRRE | 20 (40 μL) | 200 μL |
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| MAP3K1-PARN-20-GROR | 20 (40 μL) | 200 μL |
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| MAP3K1-PARN-20-GRGO | 20 (40 μL) | 200 μL |
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| MAP3K1-PARN-20-GRGR | 20 (40 μL) | 200 μL |
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| MAP3K1-PARN-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAP3K1-PARN-20-AQRE | 20 (40 μL) | 200 μL |
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| MAP3K1-PARN-20-AQOR | 20 (40 μL) | 200 μL |
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| MAP3K1-PARN-20-AQGO | 20 (40 μL) | 200 μL |
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| MAP3K1-PARN-20-AQGR | 20 (40 μL) | 200 μL |
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| MAP3K1-PARN-20-AQAQ | 20 (40 μL) | 200 μL |
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MAP3K1 Gene Summary
The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012]
Gene Name: Mitogen-activated Protein Kinase Kinase Kinase 1
Chromosome: CHR5: 56110899 -56191978
Locus: 5q11.2
PARN Gene Summary
The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Name: Poly(A)-specific Ribonuclease
Chromosome: CHR16: 14529556 -14724128
Locus: 16p13.12
Gene Diseases
The MAP3K1 PARN Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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