MAP2K5-RAB27A Fusion FISH Probe
The MAP2K5-RAB27A Fusion FISH Probe is used to confirm a fusion of the MAP2K5 and RAB27A genes. The fusion of the MAP2K5 and RAB27A genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAP2K5-RAB27A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAP2K5-RAB27A-20-RERE | 20 (40 μL) | 200 μL |
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| MAP2K5-RAB27A-20-REOR | 20 (40 μL) | 200 μL |
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| MAP2K5-RAB27A-20-REGO | 20 (40 μL) | 200 μL |
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| MAP2K5-RAB27A-20-REGR | 20 (40 μL) | 200 μL |
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| MAP2K5-RAB27A-20-REAQ | 20 (40 μL) | 200 μL |
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| MAP2K5-RAB27A-20-ORRE | 20 (40 μL) | 200 μL |
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| MAP2K5-RAB27A-20-OROR | 20 (40 μL) | 200 μL |
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| MAP2K5-RAB27A-20-ORGO | 20 (40 μL) | 200 μL |
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| MAP2K5-RAB27A-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAP2K5-RAB27A-20-GORE | 20 (40 μL) | 200 μL |
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| MAP2K5-RAB27A-20-GOOR | 20 (40 μL) | 200 μL |
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| MAP2K5-RAB27A-20-GOGO | 20 (40 μL) | 200 μL |
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| MAP2K5-RAB27A-20-GOGR | 20 (40 μL) | 200 μL |
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| MAP2K5-RAB27A-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAP2K5-RAB27A-20-GRRE | 20 (40 μL) | 200 μL |
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| MAP2K5-RAB27A-20-GROR | 20 (40 μL) | 200 μL |
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| MAP2K5-RAB27A-20-GRGO | 20 (40 μL) | 200 μL |
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| MAP2K5-RAB27A-20-GRGR | 20 (40 μL) | 200 μL |
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| MAP2K5-RAB27A-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAP2K5-RAB27A-20-AQRE | 20 (40 μL) | 200 μL |
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| MAP2K5-RAB27A-20-AQOR | 20 (40 μL) | 200 μL |
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| MAP2K5-RAB27A-20-AQGO | 20 (40 μL) | 200 μL |
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| MAP2K5-RAB27A-20-AQGR | 20 (40 μL) | 200 μL |
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| MAP2K5-RAB27A-20-AQAQ | 20 (40 μL) | 200 μL |
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MAP2K5 Gene Summary
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]
Gene Name: Mitogen-activated Protein Kinase Kinase 5
Chromosome: CHR15: 67835020 -68099455
Locus: 15q23
RAB27A Gene Summary
The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Gene Name: RAB27A, Member RAS Oncogene Family
Chromosome: CHR15: 55495163 -55582013
Locus: 15q21.3
Gene Diseases
The MAP2K5 RAB27A Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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