MAP2K3-NKAIN3 Fusion FISH Probe
The MAP2K3-NKAIN3 Fusion FISH Probe is used to confirm a fusion of the MAP2K3 and NKAIN3 genes. The fusion of the MAP2K3 and NKAIN3 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MAP2K3-NKAIN3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| MAP2K3-NKAIN3-20-RERE | 20 (40 μL) | 200 μL |
|
|
| MAP2K3-NKAIN3-20-REOR | 20 (40 μL) | 200 μL |
|
|
| MAP2K3-NKAIN3-20-REGO | 20 (40 μL) | 200 μL |
|
|
| MAP2K3-NKAIN3-20-REGR | 20 (40 μL) | 200 μL |
|
|
| MAP2K3-NKAIN3-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| MAP2K3-NKAIN3-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| MAP2K3-NKAIN3-20-OROR | 20 (40 μL) | 200 μL |
|
|
| MAP2K3-NKAIN3-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| MAP2K3-NKAIN3-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| MAP2K3-NKAIN3-20-GORE | 20 (40 μL) | 200 μL |
|
|
| MAP2K3-NKAIN3-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| MAP2K3-NKAIN3-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| MAP2K3-NKAIN3-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| MAP2K3-NKAIN3-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| MAP2K3-NKAIN3-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| MAP2K3-NKAIN3-20-GROR | 20 (40 μL) | 200 μL |
|
|
| MAP2K3-NKAIN3-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| MAP2K3-NKAIN3-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| MAP2K3-NKAIN3-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| MAP2K3-NKAIN3-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| MAP2K3-NKAIN3-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| MAP2K3-NKAIN3-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| MAP2K3-NKAIN3-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| MAP2K3-NKAIN3-20-AQAQ | 20 (40 μL) | 200 μL |
|
MAP2K3 Gene Summary
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Mitogen-activated Protein Kinase Kinase 3
Chromosome: CHR17: 21187967 -21218551
Locus: 17p11.2
NKAIN3 Gene Summary
NKAIN3 is a member of a family of mammalian proteins (see NKAIN1; MIM 612871) with similarity to Drosophila Nkain (Gorokhova et al., 2007 [PubMed 17606467]).[supplied by OMIM, Jun 2009]
Gene Name: Sodium/potassium Transporting ATPase Interacting 3
Chromosome: CHR8: 63161500 -63903628
Locus: 8q12.3
Gene Diseases
The MAP2K3 NKAIN3 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|