MAP2K2-PSMD9 Fusion FISH Probe
The MAP2K2-PSMD9 Fusion FISH Probe is used to confirm a fusion of the MAP2K2 and PSMD9 genes. The fusion of the MAP2K2 and PSMD9 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAP2K2-PSMD9-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAP2K2-PSMD9-20-RERE | 20 (40 μL) | 200 μL |
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| MAP2K2-PSMD9-20-REOR | 20 (40 μL) | 200 μL |
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| MAP2K2-PSMD9-20-REGO | 20 (40 μL) | 200 μL |
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| MAP2K2-PSMD9-20-REGR | 20 (40 μL) | 200 μL |
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| MAP2K2-PSMD9-20-REAQ | 20 (40 μL) | 200 μL |
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| MAP2K2-PSMD9-20-ORRE | 20 (40 μL) | 200 μL |
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| MAP2K2-PSMD9-20-OROR | 20 (40 μL) | 200 μL |
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| MAP2K2-PSMD9-20-ORGO | 20 (40 μL) | 200 μL |
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| MAP2K2-PSMD9-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAP2K2-PSMD9-20-GORE | 20 (40 μL) | 200 μL |
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| MAP2K2-PSMD9-20-GOOR | 20 (40 μL) | 200 μL |
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| MAP2K2-PSMD9-20-GOGO | 20 (40 μL) | 200 μL |
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| MAP2K2-PSMD9-20-GOGR | 20 (40 μL) | 200 μL |
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| MAP2K2-PSMD9-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAP2K2-PSMD9-20-GRRE | 20 (40 μL) | 200 μL |
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| MAP2K2-PSMD9-20-GROR | 20 (40 μL) | 200 μL |
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| MAP2K2-PSMD9-20-GRGO | 20 (40 μL) | 200 μL |
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| MAP2K2-PSMD9-20-GRGR | 20 (40 μL) | 200 μL |
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| MAP2K2-PSMD9-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAP2K2-PSMD9-20-AQRE | 20 (40 μL) | 200 μL |
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| MAP2K2-PSMD9-20-AQOR | 20 (40 μL) | 200 μL |
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| MAP2K2-PSMD9-20-AQGO | 20 (40 μL) | 200 μL |
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| MAP2K2-PSMD9-20-AQGR | 20 (40 μL) | 200 μL |
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| MAP2K2-PSMD9-20-AQAQ | 20 (40 μL) | 200 μL |
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MAP2K2 Gene Summary
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Mitogen-activated Protein Kinase Kinase 2
Chromosome: CHR19: 4090319 -4124126
Locus: 19p13.3
PSMD9 Gene Summary
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Gene Name: Proteasome 26S Subunit, Non-ATPase 9
Chromosome: CHR12: 122326645 -122355771
Locus: 12q24.31
Gene Diseases
The MAP2K2 PSMD9 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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