MANF-SETD2 Fusion FISH Probe
The MANF-SETD2 Fusion FISH Probe is used to confirm a fusion of the MANF and SETD2 genes. The fusion of the MANF and SETD2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MANF-SETD2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MANF-SETD2-20-RERE | 20 (40 μL) | 200 μL |
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| MANF-SETD2-20-REOR | 20 (40 μL) | 200 μL |
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| MANF-SETD2-20-REGO | 20 (40 μL) | 200 μL |
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| MANF-SETD2-20-REGR | 20 (40 μL) | 200 μL |
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| MANF-SETD2-20-REAQ | 20 (40 μL) | 200 μL |
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| MANF-SETD2-20-ORRE | 20 (40 μL) | 200 μL |
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| MANF-SETD2-20-OROR | 20 (40 μL) | 200 μL |
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| MANF-SETD2-20-ORGO | 20 (40 μL) | 200 μL |
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| MANF-SETD2-20-ORAQ | 20 (40 μL) | 200 μL |
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| MANF-SETD2-20-GORE | 20 (40 μL) | 200 μL |
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| MANF-SETD2-20-GOOR | 20 (40 μL) | 200 μL |
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| MANF-SETD2-20-GOGO | 20 (40 μL) | 200 μL |
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| MANF-SETD2-20-GOGR | 20 (40 μL) | 200 μL |
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| MANF-SETD2-20-GOAQ | 20 (40 μL) | 200 μL |
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| MANF-SETD2-20-GRRE | 20 (40 μL) | 200 μL |
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| MANF-SETD2-20-GROR | 20 (40 μL) | 200 μL |
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| MANF-SETD2-20-GRGO | 20 (40 μL) | 200 μL |
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| MANF-SETD2-20-GRGR | 20 (40 μL) | 200 μL |
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| MANF-SETD2-20-GRAQ | 20 (40 μL) | 200 μL |
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| MANF-SETD2-20-AQRE | 20 (40 μL) | 200 μL |
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| MANF-SETD2-20-AQOR | 20 (40 μL) | 200 μL |
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| MANF-SETD2-20-AQGO | 20 (40 μL) | 200 μL |
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| MANF-SETD2-20-AQGR | 20 (40 μL) | 200 μL |
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| MANF-SETD2-20-AQAQ | 20 (40 μL) | 200 μL |
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MANF Gene Summary
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014]
Gene Name: Mesencephalic Astrocyte Derived Neurotrophic Factor
Chromosome: CHR3: 51422691 -51426828
Locus: 3p21.2
SETD2 Gene Summary
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008]
Gene Name: SET Domain Containing 2
Chromosome: CHR3: 47057897 -47205467
Locus: 3p21.31
Gene Diseases
The MANF SETD2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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