MAN1A2-RNF216 Fusion FISH Probe
The MAN1A2-RNF216 Fusion FISH Probe is used to confirm a fusion of the MAN1A2 and RNF216 genes. The fusion of the MAN1A2 and RNF216 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAN1A2-RNF216-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAN1A2-RNF216-20-RERE | 20 (40 μL) | 200 μL |
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| MAN1A2-RNF216-20-REOR | 20 (40 μL) | 200 μL |
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| MAN1A2-RNF216-20-REGO | 20 (40 μL) | 200 μL |
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| MAN1A2-RNF216-20-REGR | 20 (40 μL) | 200 μL |
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| MAN1A2-RNF216-20-REAQ | 20 (40 μL) | 200 μL |
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| MAN1A2-RNF216-20-ORRE | 20 (40 μL) | 200 μL |
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| MAN1A2-RNF216-20-OROR | 20 (40 μL) | 200 μL |
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| MAN1A2-RNF216-20-ORGO | 20 (40 μL) | 200 μL |
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| MAN1A2-RNF216-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAN1A2-RNF216-20-GORE | 20 (40 μL) | 200 μL |
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| MAN1A2-RNF216-20-GOOR | 20 (40 μL) | 200 μL |
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| MAN1A2-RNF216-20-GOGO | 20 (40 μL) | 200 μL |
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| MAN1A2-RNF216-20-GOGR | 20 (40 μL) | 200 μL |
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| MAN1A2-RNF216-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAN1A2-RNF216-20-GRRE | 20 (40 μL) | 200 μL |
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| MAN1A2-RNF216-20-GROR | 20 (40 μL) | 200 μL |
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| MAN1A2-RNF216-20-GRGO | 20 (40 μL) | 200 μL |
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| MAN1A2-RNF216-20-GRGR | 20 (40 μL) | 200 μL |
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| MAN1A2-RNF216-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAN1A2-RNF216-20-AQRE | 20 (40 μL) | 200 μL |
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| MAN1A2-RNF216-20-AQOR | 20 (40 μL) | 200 μL |
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| MAN1A2-RNF216-20-AQGO | 20 (40 μL) | 200 μL |
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| MAN1A2-RNF216-20-AQGR | 20 (40 μL) | 200 μL |
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| MAN1A2-RNF216-20-AQAQ | 20 (40 μL) | 200 μL |
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MAN1A2 Gene Summary
Alpha-mannosidases function at different stages of N-glycan maturation in mammalian cells. See MAN2A1 (MIM 154582) for general information.[supplied by OMIM, Mar 2008]
Gene Name: Mannosidase Alpha Class 1A Member 2
Chromosome: CHR1: 117910084 -118068320
Locus: 1p12
RNF216 Gene Summary
This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known. [provided by RefSeq, Jul 2008]
Gene Name: Ring Finger Protein 216
Chromosome: CHR7: 5659671 -5821361
Locus: 7p22.1
Gene Diseases
The MAN1A2 RNF216 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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