MAML2-CNTN5 Fusion FISH Probe
The MAML2-CNTN5 Fusion FISH Probe is used to confirm a fusion of the MAML2 and CNTN5 genes. The fusion of the MAML2 and CNTN5 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAML2-CNTN5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAML2-CNTN5-20-RERE | 20 (40 μL) | 200 μL |
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| MAML2-CNTN5-20-REOR | 20 (40 μL) | 200 μL |
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| MAML2-CNTN5-20-REGO | 20 (40 μL) | 200 μL |
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| MAML2-CNTN5-20-REGR | 20 (40 μL) | 200 μL |
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| MAML2-CNTN5-20-REAQ | 20 (40 μL) | 200 μL |
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| MAML2-CNTN5-20-ORRE | 20 (40 μL) | 200 μL |
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| MAML2-CNTN5-20-OROR | 20 (40 μL) | 200 μL |
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| MAML2-CNTN5-20-ORGO | 20 (40 μL) | 200 μL |
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| MAML2-CNTN5-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAML2-CNTN5-20-GORE | 20 (40 μL) | 200 μL |
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| MAML2-CNTN5-20-GOOR | 20 (40 μL) | 200 μL |
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| MAML2-CNTN5-20-GOGO | 20 (40 μL) | 200 μL |
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| MAML2-CNTN5-20-GOGR | 20 (40 μL) | 200 μL |
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| MAML2-CNTN5-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAML2-CNTN5-20-GRRE | 20 (40 μL) | 200 μL |
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| MAML2-CNTN5-20-GROR | 20 (40 μL) | 200 μL |
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| MAML2-CNTN5-20-GRGO | 20 (40 μL) | 200 μL |
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| MAML2-CNTN5-20-GRGR | 20 (40 μL) | 200 μL |
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| MAML2-CNTN5-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAML2-CNTN5-20-AQRE | 20 (40 μL) | 200 μL |
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| MAML2-CNTN5-20-AQOR | 20 (40 μL) | 200 μL |
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| MAML2-CNTN5-20-AQGO | 20 (40 μL) | 200 μL |
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| MAML2-CNTN5-20-AQGR | 20 (40 μL) | 200 μL |
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| MAML2-CNTN5-20-AQAQ | 20 (40 μL) | 200 μL |
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CNTN5 Gene Summary
The protein encoded by this gene is a member of the immunoglobulin superfamily, and contactin family, which mediate cell surface interactions during nervous system development. This protein is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Gene Name: Contactin 5
Chromosome: CHR11: 98891705 -100229616
Locus: 11q22.1
MAML2 Gene Summary
The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed. [provided by RefSeq, Jan 2015]
Gene Name: Mastermind Like Transcriptional Coactivator 2
Chromosome: CHR11: 95711439 -96076344
Locus: 11q21
Gene Diseases
The MAML2 CNTN5 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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