MAML2-BCAS4 Fusion FISH Probe
The MAML2-BCAS4 Fusion FISH Probe is used to confirm a fusion of the MAML2 and BCAS4 genes. The fusion of the MAML2 and BCAS4 genes has been associated with Pheochromocytoma And Paraganglioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MAML2-BCAS4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| MAML2-BCAS4-20-RERE | 20 (40 μL) | 200 μL |
|
|
| MAML2-BCAS4-20-REOR | 20 (40 μL) | 200 μL |
|
|
| MAML2-BCAS4-20-REGO | 20 (40 μL) | 200 μL |
|
|
| MAML2-BCAS4-20-REGR | 20 (40 μL) | 200 μL |
|
|
| MAML2-BCAS4-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| MAML2-BCAS4-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| MAML2-BCAS4-20-OROR | 20 (40 μL) | 200 μL |
|
|
| MAML2-BCAS4-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| MAML2-BCAS4-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| MAML2-BCAS4-20-GORE | 20 (40 μL) | 200 μL |
|
|
| MAML2-BCAS4-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| MAML2-BCAS4-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| MAML2-BCAS4-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| MAML2-BCAS4-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| MAML2-BCAS4-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| MAML2-BCAS4-20-GROR | 20 (40 μL) | 200 μL |
|
|
| MAML2-BCAS4-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| MAML2-BCAS4-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| MAML2-BCAS4-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| MAML2-BCAS4-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| MAML2-BCAS4-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| MAML2-BCAS4-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| MAML2-BCAS4-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| MAML2-BCAS4-20-AQAQ | 20 (40 μL) | 200 μL |
|
BCAS4 Gene Summary
The Breast Carcinoma Amplified Sequence 4 (BCAS4) gene is located on chr20 :49411466-49493714 at 20q13.13.
Gene Name: Breast Carcinoma Amplified Sequence 4
Chromosome: CHR20: 49411466 -49493714
Locus: 20q13.13
MAML2 Gene Summary
The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed. [provided by RefSeq, Jan 2015]
Gene Name: Mastermind Like Transcriptional Coactivator 2
Chromosome: CHR11: 95711439 -96076344
Locus: 11q21
Gene Diseases
The MAML2 BCAS4 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Pheochromocytoma And Paraganglioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|