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MAML2-BCAS4 Fusion FISH Probe

The MAML2-BCAS4 Fusion FISH Probe is used to confirm a fusion of the MAML2 and BCAS4 genes. The fusion of the MAML2 and BCAS4 genes has been associated with Pheochromocytoma And Paraganglioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
MAML2-BCAS4-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
MAML2-BCAS4-20-RERE 20 (40 μL) 200 μL
MAML2-BCAS4-20-REOR 20 (40 μL) 200 μL
MAML2-BCAS4-20-REGO 20 (40 μL) 200 μL
MAML2-BCAS4-20-REGR 20 (40 μL) 200 μL
MAML2-BCAS4-20-REAQ 20 (40 μL) 200 μL
MAML2-BCAS4-20-ORRE 20 (40 μL) 200 μL
MAML2-BCAS4-20-OROR 20 (40 μL) 200 μL
MAML2-BCAS4-20-ORGO 20 (40 μL) 200 μL
MAML2-BCAS4-20-ORAQ 20 (40 μL) 200 μL
MAML2-BCAS4-20-GORE 20 (40 μL) 200 μL
MAML2-BCAS4-20-GOOR 20 (40 μL) 200 μL
MAML2-BCAS4-20-GOGO 20 (40 μL) 200 μL
MAML2-BCAS4-20-GOGR 20 (40 μL) 200 μL
MAML2-BCAS4-20-GOAQ 20 (40 μL) 200 μL
MAML2-BCAS4-20-GRRE 20 (40 μL) 200 μL
MAML2-BCAS4-20-GROR 20 (40 μL) 200 μL
MAML2-BCAS4-20-GRGO 20 (40 μL) 200 μL
MAML2-BCAS4-20-GRGR 20 (40 μL) 200 μL
MAML2-BCAS4-20-GRAQ 20 (40 μL) 200 μL
MAML2-BCAS4-20-AQRE 20 (40 μL) 200 μL
MAML2-BCAS4-20-AQOR 20 (40 μL) 200 μL
MAML2-BCAS4-20-AQGO 20 (40 μL) 200 μL
MAML2-BCAS4-20-AQGR 20 (40 μL) 200 μL
MAML2-BCAS4-20-AQAQ 20 (40 μL) 200 μL

BCAS4 Gene Summary

The Breast Carcinoma Amplified Sequence 4 (BCAS4) gene is located on chr20 :49411466-49493714 at 20q13.13.

Gene Name: Breast Carcinoma Amplified Sequence 4

Chromosome: CHR20: 49411466 -49493714

Locus: 20q13.13

MAML2 Gene Summary

The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed. [provided by RefSeq, Jan 2015]

Gene Name: Mastermind Like Transcriptional Coactivator 2

Chromosome: CHR11: 95711439 -96076344

Locus: 11q21

Gene Diseases

The MAML2 BCAS4 Fusion has been associated with the following diseases:

Disease Name
Pheochromocytoma And Paraganglioma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.