MAGI1-DPH3 Fusion FISH Probe
The MAGI1-DPH3 Fusion FISH Probe is used to confirm a fusion of the MAGI1 and DPH3 genes. The fusion of the MAGI1 and DPH3 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAGI1-DPH3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAGI1-DPH3-20-RERE | 20 (40 μL) | 200 μL |
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| MAGI1-DPH3-20-REOR | 20 (40 μL) | 200 μL |
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| MAGI1-DPH3-20-REGO | 20 (40 μL) | 200 μL |
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| MAGI1-DPH3-20-REGR | 20 (40 μL) | 200 μL |
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| MAGI1-DPH3-20-REAQ | 20 (40 μL) | 200 μL |
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| MAGI1-DPH3-20-ORRE | 20 (40 μL) | 200 μL |
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| MAGI1-DPH3-20-OROR | 20 (40 μL) | 200 μL |
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| MAGI1-DPH3-20-ORGO | 20 (40 μL) | 200 μL |
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| MAGI1-DPH3-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAGI1-DPH3-20-GORE | 20 (40 μL) | 200 μL |
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| MAGI1-DPH3-20-GOOR | 20 (40 μL) | 200 μL |
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| MAGI1-DPH3-20-GOGO | 20 (40 μL) | 200 μL |
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| MAGI1-DPH3-20-GOGR | 20 (40 μL) | 200 μL |
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| MAGI1-DPH3-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAGI1-DPH3-20-GRRE | 20 (40 μL) | 200 μL |
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| MAGI1-DPH3-20-GROR | 20 (40 μL) | 200 μL |
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| MAGI1-DPH3-20-GRGO | 20 (40 μL) | 200 μL |
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| MAGI1-DPH3-20-GRGR | 20 (40 μL) | 200 μL |
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| MAGI1-DPH3-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAGI1-DPH3-20-AQRE | 20 (40 μL) | 200 μL |
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| MAGI1-DPH3-20-AQOR | 20 (40 μL) | 200 μL |
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| MAGI1-DPH3-20-AQGO | 20 (40 μL) | 200 μL |
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| MAGI1-DPH3-20-AQGR | 20 (40 μL) | 200 μL |
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| MAGI1-DPH3-20-AQAQ | 20 (40 μL) | 200 μL |
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MAGI1 Gene Summary
The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Membrane Associated Guanylate Kinase, WW And PDZ Domain Containing 1
Chromosome: CHR3: 65339905 -66024509
Locus: 3p14.1
DPH3 Gene Summary
This gene encodes a CSL zinc finger-containing protein that is required for dipthamide biosynthesis. The encoded protein is necessary for the initial step in the modification of a histidine residue in elongation factor-2 to diphthamide. This modified residue is a target for ADP ribosylation by the bacterial toxins diphtheria toxin and Pseudomonas exotoxin A. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Feb 2009]
Gene Name: Diphthamide Biosynthesis 3
Chromosome: CHR3: 16298567 -16306496
Locus: 3p25.1
Gene Diseases
The MAGI1 DPH3 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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