MAGED2-NDUFV1 Fusion FISH Probe
The MAGED2-NDUFV1 Fusion FISH Probe is used to confirm a fusion of the MAGED2 and NDUFV1 genes. The fusion of the MAGED2 and NDUFV1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAGED2-NDUFV1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAGED2-NDUFV1-20-RERE | 20 (40 μL) | 200 μL |
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| MAGED2-NDUFV1-20-REOR | 20 (40 μL) | 200 μL |
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| MAGED2-NDUFV1-20-REGO | 20 (40 μL) | 200 μL |
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| MAGED2-NDUFV1-20-REGR | 20 (40 μL) | 200 μL |
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| MAGED2-NDUFV1-20-REAQ | 20 (40 μL) | 200 μL |
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| MAGED2-NDUFV1-20-ORRE | 20 (40 μL) | 200 μL |
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| MAGED2-NDUFV1-20-OROR | 20 (40 μL) | 200 μL |
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| MAGED2-NDUFV1-20-ORGO | 20 (40 μL) | 200 μL |
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| MAGED2-NDUFV1-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAGED2-NDUFV1-20-GORE | 20 (40 μL) | 200 μL |
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| MAGED2-NDUFV1-20-GOOR | 20 (40 μL) | 200 μL |
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| MAGED2-NDUFV1-20-GOGO | 20 (40 μL) | 200 μL |
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| MAGED2-NDUFV1-20-GOGR | 20 (40 μL) | 200 μL |
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| MAGED2-NDUFV1-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAGED2-NDUFV1-20-GRRE | 20 (40 μL) | 200 μL |
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| MAGED2-NDUFV1-20-GROR | 20 (40 μL) | 200 μL |
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| MAGED2-NDUFV1-20-GRGO | 20 (40 μL) | 200 μL |
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| MAGED2-NDUFV1-20-GRGR | 20 (40 μL) | 200 μL |
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| MAGED2-NDUFV1-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAGED2-NDUFV1-20-AQRE | 20 (40 μL) | 200 μL |
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| MAGED2-NDUFV1-20-AQOR | 20 (40 μL) | 200 μL |
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| MAGED2-NDUFV1-20-AQGO | 20 (40 μL) | 200 μL |
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| MAGED2-NDUFV1-20-AQGR | 20 (40 μL) | 200 μL |
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| MAGED2-NDUFV1-20-AQAQ | 20 (40 μL) | 200 μL |
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NDUFV1 Gene Summary
The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
Gene Name: NADH:ubiquinone Oxidoreductase Core Subunit V1
Chromosome: CHR11: 67374322 -67380012
Locus: 11q13.2
MAGED2 Gene Summary
This gene is a member of the MAGED gene family. The MAGED genes are clustered on chromosome Xp11. This gene is located in Xp11.2, a hot spot for X-linked intellectual disability (XLID). Mutations in this gene cause a form of transient antenatal Bartter's syndrome. This gene may also be involved in several types of cancer, including breast cancer and melanoma. The protein encoded by this gene is progressively recruited from the cytoplasm to the nucleoplasm during the interphase and after nucleolar stress and is thus thought to play a role in cell cycle regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
Gene Name: MAGE Family Member D2
Chromosome: CHRX: 54834170 -54842445
Locus: Xp11.21
Gene Diseases
The MAGED2 NDUFV1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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