MAFK-KCTD5 Fusion FISH Probe
The MAFK-KCTD5 Fusion FISH Probe is used to confirm a fusion of the MAFK and KCTD5 genes. The fusion of the MAFK and KCTD5 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAFK-KCTD5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAFK-KCTD5-20-RERE | 20 (40 μL) | 200 μL |
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| MAFK-KCTD5-20-REOR | 20 (40 μL) | 200 μL |
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| MAFK-KCTD5-20-REGO | 20 (40 μL) | 200 μL |
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| MAFK-KCTD5-20-REGR | 20 (40 μL) | 200 μL |
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| MAFK-KCTD5-20-REAQ | 20 (40 μL) | 200 μL |
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| MAFK-KCTD5-20-ORRE | 20 (40 μL) | 200 μL |
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| MAFK-KCTD5-20-OROR | 20 (40 μL) | 200 μL |
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| MAFK-KCTD5-20-ORGO | 20 (40 μL) | 200 μL |
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| MAFK-KCTD5-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAFK-KCTD5-20-GORE | 20 (40 μL) | 200 μL |
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| MAFK-KCTD5-20-GOOR | 20 (40 μL) | 200 μL |
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| MAFK-KCTD5-20-GOGO | 20 (40 μL) | 200 μL |
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| MAFK-KCTD5-20-GOGR | 20 (40 μL) | 200 μL |
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| MAFK-KCTD5-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAFK-KCTD5-20-GRRE | 20 (40 μL) | 200 μL |
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| MAFK-KCTD5-20-GROR | 20 (40 μL) | 200 μL |
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| MAFK-KCTD5-20-GRGO | 20 (40 μL) | 200 μL |
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| MAFK-KCTD5-20-GRGR | 20 (40 μL) | 200 μL |
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| MAFK-KCTD5-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAFK-KCTD5-20-AQRE | 20 (40 μL) | 200 μL |
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| MAFK-KCTD5-20-AQOR | 20 (40 μL) | 200 μL |
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| MAFK-KCTD5-20-AQGO | 20 (40 μL) | 200 μL |
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| MAFK-KCTD5-20-AQGR | 20 (40 μL) | 200 μL |
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| MAFK-KCTD5-20-AQAQ | 20 (40 μL) | 200 μL |
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MAFK Gene Summary
The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 612386). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM, Nov 2008]
Gene Name: MAF BZIP Transcription Factor K
Chromosome: CHR7: 1570367 -1582679
Locus: 7p22.3
KCTD5 Gene Summary
The Potassium Channel Tetramerization Domain Containing 5 (KCTD5) gene is located on chr16 :2732494-2759031 at 16p13.3.
Gene Name: Potassium Channel Tetramerization Domain Containing 5
Chromosome: CHR16: 2732494 -2759031
Locus: 16p13.3
Gene Diseases
The MAFK KCTD5 Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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