MADD-PIK3C2A Fusion FISH Probe
The MADD-PIK3C2A Fusion FISH Probe is used to confirm a fusion of the MADD and PIK3C2A genes. The fusion of the MADD and PIK3C2A genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MADD-PIK3C2A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MADD-PIK3C2A-20-RERE | 20 (40 μL) | 200 μL |
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| MADD-PIK3C2A-20-REOR | 20 (40 μL) | 200 μL |
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| MADD-PIK3C2A-20-REGO | 20 (40 μL) | 200 μL |
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| MADD-PIK3C2A-20-REGR | 20 (40 μL) | 200 μL |
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| MADD-PIK3C2A-20-REAQ | 20 (40 μL) | 200 μL |
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| MADD-PIK3C2A-20-ORRE | 20 (40 μL) | 200 μL |
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| MADD-PIK3C2A-20-OROR | 20 (40 μL) | 200 μL |
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| MADD-PIK3C2A-20-ORGO | 20 (40 μL) | 200 μL |
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| MADD-PIK3C2A-20-ORAQ | 20 (40 μL) | 200 μL |
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| MADD-PIK3C2A-20-GORE | 20 (40 μL) | 200 μL |
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| MADD-PIK3C2A-20-GOOR | 20 (40 μL) | 200 μL |
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| MADD-PIK3C2A-20-GOGO | 20 (40 μL) | 200 μL |
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| MADD-PIK3C2A-20-GOGR | 20 (40 μL) | 200 μL |
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| MADD-PIK3C2A-20-GOAQ | 20 (40 μL) | 200 μL |
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| MADD-PIK3C2A-20-GRRE | 20 (40 μL) | 200 μL |
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| MADD-PIK3C2A-20-GROR | 20 (40 μL) | 200 μL |
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| MADD-PIK3C2A-20-GRGO | 20 (40 μL) | 200 μL |
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| MADD-PIK3C2A-20-GRGR | 20 (40 μL) | 200 μL |
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| MADD-PIK3C2A-20-GRAQ | 20 (40 μL) | 200 μL |
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| MADD-PIK3C2A-20-AQRE | 20 (40 μL) | 200 μL |
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| MADD-PIK3C2A-20-AQOR | 20 (40 μL) | 200 μL |
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| MADD-PIK3C2A-20-AQGO | 20 (40 μL) | 200 μL |
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| MADD-PIK3C2A-20-AQGR | 20 (40 μL) | 200 μL |
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| MADD-PIK3C2A-20-AQAQ | 20 (40 μL) | 200 μL |
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PIK3C2A Gene Summary
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008]
Gene Name: Phosphatidylinositol-4-phosphate 3-kinase Catalytic Subunit Type 2 Alpha
Chromosome: CHR11: 17108123 -17191354
Locus: 11p15.1
MADD Gene Summary
Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: MAP Kinase Activating Death Domain
Chromosome: CHR11: 47290926 -47351582
Locus: 11p11.2
Gene Diseases
The MADD PIK3C2A Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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