MADD-DDB2 Fusion FISH Probe
The MADD-DDB2 Fusion FISH Probe is used to confirm a fusion of the MADD and DDB2 genes. The fusion of the MADD and DDB2 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MADD-DDB2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MADD-DDB2-20-RERE | 20 (40 μL) | 200 μL |
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| MADD-DDB2-20-REOR | 20 (40 μL) | 200 μL |
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| MADD-DDB2-20-REGO | 20 (40 μL) | 200 μL |
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| MADD-DDB2-20-REGR | 20 (40 μL) | 200 μL |
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| MADD-DDB2-20-REAQ | 20 (40 μL) | 200 μL |
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| MADD-DDB2-20-ORRE | 20 (40 μL) | 200 μL |
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| MADD-DDB2-20-OROR | 20 (40 μL) | 200 μL |
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| MADD-DDB2-20-ORGO | 20 (40 μL) | 200 μL |
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| MADD-DDB2-20-ORAQ | 20 (40 μL) | 200 μL |
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| MADD-DDB2-20-GORE | 20 (40 μL) | 200 μL |
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| MADD-DDB2-20-GOOR | 20 (40 μL) | 200 μL |
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| MADD-DDB2-20-GOGO | 20 (40 μL) | 200 μL |
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| MADD-DDB2-20-GOGR | 20 (40 μL) | 200 μL |
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| MADD-DDB2-20-GOAQ | 20 (40 μL) | 200 μL |
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| MADD-DDB2-20-GRRE | 20 (40 μL) | 200 μL |
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| MADD-DDB2-20-GROR | 20 (40 μL) | 200 μL |
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| MADD-DDB2-20-GRGO | 20 (40 μL) | 200 μL |
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| MADD-DDB2-20-GRGR | 20 (40 μL) | 200 μL |
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| MADD-DDB2-20-GRAQ | 20 (40 μL) | 200 μL |
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| MADD-DDB2-20-AQRE | 20 (40 μL) | 200 μL |
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| MADD-DDB2-20-AQOR | 20 (40 μL) | 200 μL |
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| MADD-DDB2-20-AQGO | 20 (40 μL) | 200 μL |
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| MADD-DDB2-20-AQGR | 20 (40 μL) | 200 μL |
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| MADD-DDB2-20-AQAQ | 20 (40 μL) | 200 μL |
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DDB2 Gene Summary
This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Gene Name: Damage Specific DNA Binding Protein 2
Chromosome: CHR11: 47236492 -47260769
Locus: 11p11.2
MADD Gene Summary
Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: MAP Kinase Activating Death Domain
Chromosome: CHR11: 47290926 -47351582
Locus: 11p11.2
Gene Diseases
The MADD DDB2 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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