MADD-ASIP Fusion FISH Probe
The MADD-ASIP Fusion FISH Probe is used to confirm a fusion of the MADD and ASIP genes. The fusion of the MADD and ASIP genes has been associated with Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MADD-ASIP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MADD-ASIP-20-RERE | 20 (40 μL) | 200 μL |
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| MADD-ASIP-20-REOR | 20 (40 μL) | 200 μL |
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| MADD-ASIP-20-REGO | 20 (40 μL) | 200 μL |
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| MADD-ASIP-20-REGR | 20 (40 μL) | 200 μL |
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| MADD-ASIP-20-REAQ | 20 (40 μL) | 200 μL |
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| MADD-ASIP-20-ORRE | 20 (40 μL) | 200 μL |
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| MADD-ASIP-20-OROR | 20 (40 μL) | 200 μL |
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| MADD-ASIP-20-ORGO | 20 (40 μL) | 200 μL |
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| MADD-ASIP-20-ORAQ | 20 (40 μL) | 200 μL |
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| MADD-ASIP-20-GORE | 20 (40 μL) | 200 μL |
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| MADD-ASIP-20-GOOR | 20 (40 μL) | 200 μL |
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| MADD-ASIP-20-GOGO | 20 (40 μL) | 200 μL |
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| MADD-ASIP-20-GOGR | 20 (40 μL) | 200 μL |
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| MADD-ASIP-20-GOAQ | 20 (40 μL) | 200 μL |
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| MADD-ASIP-20-GRRE | 20 (40 μL) | 200 μL |
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| MADD-ASIP-20-GROR | 20 (40 μL) | 200 μL |
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| MADD-ASIP-20-GRGO | 20 (40 μL) | 200 μL |
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| MADD-ASIP-20-GRGR | 20 (40 μL) | 200 μL |
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| MADD-ASIP-20-GRAQ | 20 (40 μL) | 200 μL |
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| MADD-ASIP-20-AQRE | 20 (40 μL) | 200 μL |
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| MADD-ASIP-20-AQOR | 20 (40 μL) | 200 μL |
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| MADD-ASIP-20-AQGO | 20 (40 μL) | 200 μL |
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| MADD-ASIP-20-AQGR | 20 (40 μL) | 200 μL |
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| MADD-ASIP-20-AQAQ | 20 (40 μL) | 200 μL |
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ASIP Gene Summary
In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. [provided by RefSeq, Jul 2008]
Gene Name: Agouti Signaling Protein
Chromosome: CHR20: 32848170 -32857148
Locus: 20q11.22
MADD Gene Summary
Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: MAP Kinase Activating Death Domain
Chromosome: CHR11: 47290926 -47351582
Locus: 11p11.2
Gene Diseases
The MADD ASIP Fusion has been associated with the following diseases:
| Disease Name |
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| Adrenocortical Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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