MACROD2-SPTLC3 Fusion FISH Probe
The MACROD2-SPTLC3 Fusion FISH Probe is used to confirm a fusion of the MACROD2 and SPTLC3 genes. The fusion of the MACROD2 and SPTLC3 genes has been associated with Skin Cutaneous Melanoma, and Pheochromocytoma And Paraganglioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MACROD2-SPTLC3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MACROD2-SPTLC3-20-RERE | 20 (40 μL) | 200 μL |
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| MACROD2-SPTLC3-20-REOR | 20 (40 μL) | 200 μL |
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| MACROD2-SPTLC3-20-REGO | 20 (40 μL) | 200 μL |
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| MACROD2-SPTLC3-20-REGR | 20 (40 μL) | 200 μL |
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| MACROD2-SPTLC3-20-REAQ | 20 (40 μL) | 200 μL |
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| MACROD2-SPTLC3-20-ORRE | 20 (40 μL) | 200 μL |
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| MACROD2-SPTLC3-20-OROR | 20 (40 μL) | 200 μL |
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| MACROD2-SPTLC3-20-ORGO | 20 (40 μL) | 200 μL |
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| MACROD2-SPTLC3-20-ORAQ | 20 (40 μL) | 200 μL |
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| MACROD2-SPTLC3-20-GORE | 20 (40 μL) | 200 μL |
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| MACROD2-SPTLC3-20-GOOR | 20 (40 μL) | 200 μL |
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| MACROD2-SPTLC3-20-GOGO | 20 (40 μL) | 200 μL |
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| MACROD2-SPTLC3-20-GOGR | 20 (40 μL) | 200 μL |
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| MACROD2-SPTLC3-20-GOAQ | 20 (40 μL) | 200 μL |
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| MACROD2-SPTLC3-20-GRRE | 20 (40 μL) | 200 μL |
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| MACROD2-SPTLC3-20-GROR | 20 (40 μL) | 200 μL |
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| MACROD2-SPTLC3-20-GRGO | 20 (40 μL) | 200 μL |
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| MACROD2-SPTLC3-20-GRGR | 20 (40 μL) | 200 μL |
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| MACROD2-SPTLC3-20-GRAQ | 20 (40 μL) | 200 μL |
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| MACROD2-SPTLC3-20-AQRE | 20 (40 μL) | 200 μL |
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| MACROD2-SPTLC3-20-AQOR | 20 (40 μL) | 200 μL |
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| MACROD2-SPTLC3-20-AQGO | 20 (40 μL) | 200 μL |
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| MACROD2-SPTLC3-20-AQGR | 20 (40 μL) | 200 μL |
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| MACROD2-SPTLC3-20-AQAQ | 20 (40 μL) | 200 μL |
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SPTLC3 Gene Summary
This gene encodes a subunit of the serine palmitoyltransferase complex which catalyzes the rate-limiting step in sphingolipid biosynthesis. This subunit metabolizes lauroyl- and myristoyl-CoA and generates C14 and C16-sphingoid bases. [provided by RefSeq, Mar 2017]
Gene Name: Serine Palmitoyltransferase Long Chain Base Subunit 3
Chromosome: CHR20: 12989626 -13147411
Locus: 20p12.1
MACROD2 Gene Summary
The protein encoded by this gene is a deacetylase involved in removing ADP-ribose from mono-ADP-ribosylated proteins. The encoded protein has been shown to translocate from the nucleus to the cytoplasm upon DNA damage. [provided by RefSeq, May 2017]
Gene Name: MACRO Domain Containing 2
Chromosome: CHR20: 13976145 -16033841
Locus: 20p12.1
Gene Diseases
The MACROD2 SPTLC3 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
| Pheochromocytoma And Paraganglioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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