MACF1-INPP5B Fusion FISH Probe
The MACF1-INPP5B Fusion FISH Probe is used to confirm a fusion of the MACF1 and INPP5B genes. The fusion of the MACF1 and INPP5B genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MACF1-INPP5B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MACF1-INPP5B-20-RERE | 20 (40 μL) | 200 μL |
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| MACF1-INPP5B-20-REOR | 20 (40 μL) | 200 μL |
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| MACF1-INPP5B-20-REGO | 20 (40 μL) | 200 μL |
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| MACF1-INPP5B-20-REGR | 20 (40 μL) | 200 μL |
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| MACF1-INPP5B-20-REAQ | 20 (40 μL) | 200 μL |
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| MACF1-INPP5B-20-ORRE | 20 (40 μL) | 200 μL |
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| MACF1-INPP5B-20-OROR | 20 (40 μL) | 200 μL |
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| MACF1-INPP5B-20-ORGO | 20 (40 μL) | 200 μL |
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| MACF1-INPP5B-20-ORAQ | 20 (40 μL) | 200 μL |
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| MACF1-INPP5B-20-GORE | 20 (40 μL) | 200 μL |
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| MACF1-INPP5B-20-GOOR | 20 (40 μL) | 200 μL |
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| MACF1-INPP5B-20-GOGO | 20 (40 μL) | 200 μL |
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| MACF1-INPP5B-20-GOGR | 20 (40 μL) | 200 μL |
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| MACF1-INPP5B-20-GOAQ | 20 (40 μL) | 200 μL |
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| MACF1-INPP5B-20-GRRE | 20 (40 μL) | 200 μL |
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| MACF1-INPP5B-20-GROR | 20 (40 μL) | 200 μL |
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| MACF1-INPP5B-20-GRGO | 20 (40 μL) | 200 μL |
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| MACF1-INPP5B-20-GRGR | 20 (40 μL) | 200 μL |
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| MACF1-INPP5B-20-GRAQ | 20 (40 μL) | 200 μL |
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| MACF1-INPP5B-20-AQRE | 20 (40 μL) | 200 μL |
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| MACF1-INPP5B-20-AQOR | 20 (40 μL) | 200 μL |
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| MACF1-INPP5B-20-AQGO | 20 (40 μL) | 200 μL |
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| MACF1-INPP5B-20-AQGR | 20 (40 μL) | 200 μL |
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| MACF1-INPP5B-20-AQAQ | 20 (40 μL) | 200 μL |
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INPP5B Gene Summary
This gene encodes a member of a family of inositol polyphosphate-5-phosphatases. These enzymes function in the regulation of calcium signaling by inactivating inositol phosphates. The encoded protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2014]
Gene Name: Inositol Polyphosphate-5-phosphatase B
Chromosome: CHR1: 38326368 -38412729
Locus: 1p34.3
MACF1 Gene Summary
This gene encodes a large protein containing numerous spectrin and leucine-rich repeat (LRR) domains. The encoded protein is a member of a family of proteins that form bridges between different cytoskeletal elements. This protein facilitates actin-microtubule interactions at the cell periphery and couples the microtubule network to cellular junctions. Alternative splicing results in multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013]
Gene Name: Microtubule-actin Crosslinking Factor 1
Chromosome: CHR1: 39547088 -39952810
Locus: 1p34.3
Gene Diseases
The MACF1 INPP5B Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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