MACF1-HDAC5 Fusion FISH Probe
The MACF1-HDAC5 Fusion FISH Probe is used to confirm a fusion of the MACF1 and HDAC5 genes. The fusion of the MACF1 and HDAC5 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MACF1-HDAC5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MACF1-HDAC5-20-RERE | 20 (40 μL) | 200 μL |
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| MACF1-HDAC5-20-REOR | 20 (40 μL) | 200 μL |
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| MACF1-HDAC5-20-REGO | 20 (40 μL) | 200 μL |
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| MACF1-HDAC5-20-REGR | 20 (40 μL) | 200 μL |
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| MACF1-HDAC5-20-REAQ | 20 (40 μL) | 200 μL |
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| MACF1-HDAC5-20-ORRE | 20 (40 μL) | 200 μL |
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| MACF1-HDAC5-20-OROR | 20 (40 μL) | 200 μL |
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| MACF1-HDAC5-20-ORGO | 20 (40 μL) | 200 μL |
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| MACF1-HDAC5-20-ORAQ | 20 (40 μL) | 200 μL |
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| MACF1-HDAC5-20-GORE | 20 (40 μL) | 200 μL |
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| MACF1-HDAC5-20-GOOR | 20 (40 μL) | 200 μL |
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| MACF1-HDAC5-20-GOGO | 20 (40 μL) | 200 μL |
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| MACF1-HDAC5-20-GOGR | 20 (40 μL) | 200 μL |
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| MACF1-HDAC5-20-GOAQ | 20 (40 μL) | 200 μL |
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| MACF1-HDAC5-20-GRRE | 20 (40 μL) | 200 μL |
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| MACF1-HDAC5-20-GROR | 20 (40 μL) | 200 μL |
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| MACF1-HDAC5-20-GRGO | 20 (40 μL) | 200 μL |
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| MACF1-HDAC5-20-GRGR | 20 (40 μL) | 200 μL |
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| MACF1-HDAC5-20-GRAQ | 20 (40 μL) | 200 μL |
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| MACF1-HDAC5-20-AQRE | 20 (40 μL) | 200 μL |
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| MACF1-HDAC5-20-AQOR | 20 (40 μL) | 200 μL |
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| MACF1-HDAC5-20-AQGO | 20 (40 μL) | 200 μL |
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| MACF1-HDAC5-20-AQGR | 20 (40 μL) | 200 μL |
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| MACF1-HDAC5-20-AQAQ | 20 (40 μL) | 200 μL |
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HDAC5 Gene Summary
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Histone Deacetylase 5
Chromosome: CHR17: 42154120 -42201014
Locus: 17q21.31
MACF1 Gene Summary
This gene encodes a large protein containing numerous spectrin and leucine-rich repeat (LRR) domains. The encoded protein is a member of a family of proteins that form bridges between different cytoskeletal elements. This protein facilitates actin-microtubule interactions at the cell periphery and couples the microtubule network to cellular junctions. Alternative splicing results in multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013]
Gene Name: Microtubule-actin Crosslinking Factor 1
Chromosome: CHR1: 39547088 -39952810
Locus: 1p34.3
Gene Diseases
The MACF1 HDAC5 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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