LYZ-STAT6 Fusion FISH Probe
The LYZ-STAT6 Fusion FISH Probe is used to confirm a fusion of the LYZ and STAT6 genes. The fusion of the LYZ and STAT6 genes has been associated with Acute Myeloid Leukemia. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LYZ-STAT6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LYZ-STAT6-20-RERE | 20 (40 μL) | 200 μL |
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| LYZ-STAT6-20-REOR | 20 (40 μL) | 200 μL |
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| LYZ-STAT6-20-REGO | 20 (40 μL) | 200 μL |
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| LYZ-STAT6-20-REGR | 20 (40 μL) | 200 μL |
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| LYZ-STAT6-20-REAQ | 20 (40 μL) | 200 μL |
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| LYZ-STAT6-20-ORRE | 20 (40 μL) | 200 μL |
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| LYZ-STAT6-20-OROR | 20 (40 μL) | 200 μL |
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| LYZ-STAT6-20-ORGO | 20 (40 μL) | 200 μL |
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| LYZ-STAT6-20-ORAQ | 20 (40 μL) | 200 μL |
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| LYZ-STAT6-20-GORE | 20 (40 μL) | 200 μL |
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| LYZ-STAT6-20-GOOR | 20 (40 μL) | 200 μL |
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| LYZ-STAT6-20-GOGO | 20 (40 μL) | 200 μL |
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| LYZ-STAT6-20-GOGR | 20 (40 μL) | 200 μL |
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| LYZ-STAT6-20-GOAQ | 20 (40 μL) | 200 μL |
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| LYZ-STAT6-20-GRRE | 20 (40 μL) | 200 μL |
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| LYZ-STAT6-20-GROR | 20 (40 μL) | 200 μL |
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| LYZ-STAT6-20-GRGO | 20 (40 μL) | 200 μL |
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| LYZ-STAT6-20-GRGR | 20 (40 μL) | 200 μL |
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| LYZ-STAT6-20-GRAQ | 20 (40 μL) | 200 μL |
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| LYZ-STAT6-20-AQRE | 20 (40 μL) | 200 μL |
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| LYZ-STAT6-20-AQOR | 20 (40 μL) | 200 μL |
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| LYZ-STAT6-20-AQGO | 20 (40 μL) | 200 μL |
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| LYZ-STAT6-20-AQGR | 20 (40 μL) | 200 μL |
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| LYZ-STAT6-20-AQAQ | 20 (40 μL) | 200 μL |
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LYZ Gene Summary
This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014]
Gene Name: Lysozyme
Chromosome: CHR12: 69742133 -69748013
Locus: 12q15
STAT6 Gene Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Name: Signal Transducer And Activator Of Transcription 6
Chromosome: CHR12: 57489186 -57505196
Locus: 12q13.3
Gene Diseases
The LYZ STAT6 Fusion has been associated with the following diseases:
| Disease Name |
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| Acute Myeloid Leukemia |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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