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LYZ-STAT6 Fusion FISH Probe

The LYZ-STAT6 Fusion FISH Probe is used to confirm a fusion of the LYZ and STAT6 genes. The fusion of the LYZ and STAT6 genes has been associated with Acute Myeloid Leukemia. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
LYZ-STAT6-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
LYZ-STAT6-20-RERE 20 (40 μL) 200 μL
LYZ-STAT6-20-REOR 20 (40 μL) 200 μL
LYZ-STAT6-20-REGO 20 (40 μL) 200 μL
LYZ-STAT6-20-REGR 20 (40 μL) 200 μL
LYZ-STAT6-20-REAQ 20 (40 μL) 200 μL
LYZ-STAT6-20-ORRE 20 (40 μL) 200 μL
LYZ-STAT6-20-OROR 20 (40 μL) 200 μL
LYZ-STAT6-20-ORGO 20 (40 μL) 200 μL
LYZ-STAT6-20-ORAQ 20 (40 μL) 200 μL
LYZ-STAT6-20-GORE 20 (40 μL) 200 μL
LYZ-STAT6-20-GOOR 20 (40 μL) 200 μL
LYZ-STAT6-20-GOGO 20 (40 μL) 200 μL
LYZ-STAT6-20-GOGR 20 (40 μL) 200 μL
LYZ-STAT6-20-GOAQ 20 (40 μL) 200 μL
LYZ-STAT6-20-GRRE 20 (40 μL) 200 μL
LYZ-STAT6-20-GROR 20 (40 μL) 200 μL
LYZ-STAT6-20-GRGO 20 (40 μL) 200 μL
LYZ-STAT6-20-GRGR 20 (40 μL) 200 μL
LYZ-STAT6-20-GRAQ 20 (40 μL) 200 μL
LYZ-STAT6-20-AQRE 20 (40 μL) 200 μL
LYZ-STAT6-20-AQOR 20 (40 μL) 200 μL
LYZ-STAT6-20-AQGO 20 (40 μL) 200 μL
LYZ-STAT6-20-AQGR 20 (40 μL) 200 μL
LYZ-STAT6-20-AQAQ 20 (40 μL) 200 μL

LYZ Gene Summary

This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014]

Gene Name: Lysozyme

Chromosome: CHR12: 69742133 -69748013

Locus: 12q15

STAT6 Gene Summary

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Gene Name: Signal Transducer And Activator Of Transcription 6

Chromosome: CHR12: 57489186 -57505196

Locus: 12q13.3

Gene Diseases

The LYZ STAT6 Fusion has been associated with the following diseases:

Disease Name
Acute Myeloid Leukemia

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.