LYST-DISC1 Fusion FISH Probe
The LYST-DISC1 Fusion FISH Probe is used to confirm a fusion of the LYST and DISC1 genes. The fusion of the LYST and DISC1 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LYST-DISC1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LYST-DISC1-20-RERE | 20 (40 μL) | 200 μL |
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| LYST-DISC1-20-REOR | 20 (40 μL) | 200 μL |
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| LYST-DISC1-20-REGO | 20 (40 μL) | 200 μL |
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| LYST-DISC1-20-REGR | 20 (40 μL) | 200 μL |
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| LYST-DISC1-20-REAQ | 20 (40 μL) | 200 μL |
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| LYST-DISC1-20-ORRE | 20 (40 μL) | 200 μL |
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| LYST-DISC1-20-OROR | 20 (40 μL) | 200 μL |
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| LYST-DISC1-20-ORGO | 20 (40 μL) | 200 μL |
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| LYST-DISC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| LYST-DISC1-20-GORE | 20 (40 μL) | 200 μL |
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| LYST-DISC1-20-GOOR | 20 (40 μL) | 200 μL |
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| LYST-DISC1-20-GOGO | 20 (40 μL) | 200 μL |
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| LYST-DISC1-20-GOGR | 20 (40 μL) | 200 μL |
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| LYST-DISC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| LYST-DISC1-20-GRRE | 20 (40 μL) | 200 μL |
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| LYST-DISC1-20-GROR | 20 (40 μL) | 200 μL |
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| LYST-DISC1-20-GRGO | 20 (40 μL) | 200 μL |
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| LYST-DISC1-20-GRGR | 20 (40 μL) | 200 μL |
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| LYST-DISC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| LYST-DISC1-20-AQRE | 20 (40 μL) | 200 μL |
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| LYST-DISC1-20-AQOR | 20 (40 μL) | 200 μL |
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| LYST-DISC1-20-AQGO | 20 (40 μL) | 200 μL |
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| LYST-DISC1-20-AQGR | 20 (40 μL) | 200 μL |
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| LYST-DISC1-20-AQAQ | 20 (40 μL) | 200 μL |
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LYST Gene Summary
This gene encodes a protein that regulates intracellular protein trafficking in endosomes, and may be involved in pigmentation. Mutations in this gene are associated with Chediak-Higashi syndrome, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants, though the full-length nature of some of these variants has not been determined. [provided by RefSeq, Apr 2013]
Gene Name: Lysosomal Trafficking Regulator
Chromosome: CHR1: 235824344 -236030220
Locus: 1q42.3
DISC1 Gene Summary
This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Name: Disrupted In Schizophrenia 1
Chromosome: CHR1: 231762560 -232177019
Locus: 1q42.2
Gene Diseases
The LYST DISC1 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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