LYRM4-FARS2 Fusion FISH Probe
The LYRM4-FARS2 Fusion FISH Probe is used to confirm a fusion of the LYRM4 and FARS2 genes. The fusion of the LYRM4 and FARS2 genes has been associated with Skin Cutaneous Melanoma, and Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LYRM4-FARS2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LYRM4-FARS2-20-RERE | 20 (40 μL) | 200 μL |
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| LYRM4-FARS2-20-REOR | 20 (40 μL) | 200 μL |
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| LYRM4-FARS2-20-REGO | 20 (40 μL) | 200 μL |
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| LYRM4-FARS2-20-REGR | 20 (40 μL) | 200 μL |
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| LYRM4-FARS2-20-REAQ | 20 (40 μL) | 200 μL |
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| LYRM4-FARS2-20-ORRE | 20 (40 μL) | 200 μL |
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| LYRM4-FARS2-20-OROR | 20 (40 μL) | 200 μL |
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| LYRM4-FARS2-20-ORGO | 20 (40 μL) | 200 μL |
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| LYRM4-FARS2-20-ORAQ | 20 (40 μL) | 200 μL |
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| LYRM4-FARS2-20-GORE | 20 (40 μL) | 200 μL |
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| LYRM4-FARS2-20-GOOR | 20 (40 μL) | 200 μL |
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| LYRM4-FARS2-20-GOGO | 20 (40 μL) | 200 μL |
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| LYRM4-FARS2-20-GOGR | 20 (40 μL) | 200 μL |
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| LYRM4-FARS2-20-GOAQ | 20 (40 μL) | 200 μL |
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| LYRM4-FARS2-20-GRRE | 20 (40 μL) | 200 μL |
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| LYRM4-FARS2-20-GROR | 20 (40 μL) | 200 μL |
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| LYRM4-FARS2-20-GRGO | 20 (40 μL) | 200 μL |
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| LYRM4-FARS2-20-GRGR | 20 (40 μL) | 200 μL |
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| LYRM4-FARS2-20-GRAQ | 20 (40 μL) | 200 μL |
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| LYRM4-FARS2-20-AQRE | 20 (40 μL) | 200 μL |
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| LYRM4-FARS2-20-AQOR | 20 (40 μL) | 200 μL |
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| LYRM4-FARS2-20-AQGO | 20 (40 μL) | 200 μL |
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| LYRM4-FARS2-20-AQGR | 20 (40 μL) | 200 μL |
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| LYRM4-FARS2-20-AQAQ | 20 (40 μL) | 200 μL |
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FARS2 Gene Summary
This gene encodes a protein that transfers phenylalanine to its cognate tRNA. This protein localizes to the mitochondrion and plays a role in mitochondrial protein translation. Mutations in this gene can cause combined oxidative phosphorylation deficiency 14 (Alpers encephalopathy). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Gene Name: Phenylalanyl-tRNA Synthetase 2, Mitochondrial
Chromosome: CHR6: 5261583 -5771816
Locus: 6p25.1
LYRM4 Gene Summary
The protein encoded by this gene is found in both mitochondria and the nucleus, where it binds cysteine desulfurase and helps free inorganic sulfur for Fe/S clusters. Disruption of this gene negatively impacts mitochondrial and cytosolic iron homeostasis. [provided by RefSeq, Sep 2016]
Gene Name: LYR Motif Containing 4
Chromosome: CHR6: 5108652 -5261172
Locus: 6p25.1
Gene Diseases
The LYRM4 FARS2 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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