LUC7L2-MRPS33 Fusion FISH Probe
The LUC7L2-MRPS33 Fusion FISH Probe is used to confirm a fusion of the LUC7L2 and MRPS33 genes. The fusion of the LUC7L2 and MRPS33 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LUC7L2-MRPS33-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LUC7L2-MRPS33-20-RERE | 20 (40 μL) | 200 μL |
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| LUC7L2-MRPS33-20-REOR | 20 (40 μL) | 200 μL |
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| LUC7L2-MRPS33-20-REGO | 20 (40 μL) | 200 μL |
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| LUC7L2-MRPS33-20-REGR | 20 (40 μL) | 200 μL |
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| LUC7L2-MRPS33-20-REAQ | 20 (40 μL) | 200 μL |
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| LUC7L2-MRPS33-20-ORRE | 20 (40 μL) | 200 μL |
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| LUC7L2-MRPS33-20-OROR | 20 (40 μL) | 200 μL |
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| LUC7L2-MRPS33-20-ORGO | 20 (40 μL) | 200 μL |
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| LUC7L2-MRPS33-20-ORAQ | 20 (40 μL) | 200 μL |
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| LUC7L2-MRPS33-20-GORE | 20 (40 μL) | 200 μL |
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| LUC7L2-MRPS33-20-GOOR | 20 (40 μL) | 200 μL |
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| LUC7L2-MRPS33-20-GOGO | 20 (40 μL) | 200 μL |
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| LUC7L2-MRPS33-20-GOGR | 20 (40 μL) | 200 μL |
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| LUC7L2-MRPS33-20-GOAQ | 20 (40 μL) | 200 μL |
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| LUC7L2-MRPS33-20-GRRE | 20 (40 μL) | 200 μL |
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| LUC7L2-MRPS33-20-GROR | 20 (40 μL) | 200 μL |
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| LUC7L2-MRPS33-20-GRGO | 20 (40 μL) | 200 μL |
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| LUC7L2-MRPS33-20-GRGR | 20 (40 μL) | 200 μL |
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| LUC7L2-MRPS33-20-GRAQ | 20 (40 μL) | 200 μL |
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| LUC7L2-MRPS33-20-AQRE | 20 (40 μL) | 200 μL |
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| LUC7L2-MRPS33-20-AQOR | 20 (40 μL) | 200 μL |
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| LUC7L2-MRPS33-20-AQGO | 20 (40 μL) | 200 μL |
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| LUC7L2-MRPS33-20-AQGR | 20 (40 μL) | 200 μL |
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| LUC7L2-MRPS33-20-AQAQ | 20 (40 μL) | 200 μL |
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LUC7L2 Gene Summary
This gene encodes a protein that contains a C2H2-type zinc finger, coiled-coil region and arginine, serine-rich (RS) domain. A similar protein in mouse interacts with sodium channel modifier 1, and the encoded protein may be involved in the recognition of non-consensus splice donor sites in association with the U1 snRNP spliceosomal subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Gene Name: LUC7 Like 2, Pre-mRNA Splicing Factor
Chromosome: CHR7: 139044633 -139108200
Locus: 7q34
MRPS33 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. The 28S subunit of the mammalian mitoribosome may play a crucial and characteristic role in translation initiation. This gene encodes a 28S subunit protein that is one of the more highly conserved mitochondrial ribosomal proteins among mammals, Drosophila and C. elegans. Splice variants that differ in the 5' UTR have been found for this gene; all variants encode the same protein. Pseudogenes corresponding to this gene are found on chromosomes 1q, 4p, 4q, and 20q [provided by RefSeq, Jul 2008]
Gene Name: Mitochondrial Ribosomal Protein S33
Chromosome: CHR7: 140705960 -140714781
Locus: 7q34
Gene Diseases
The LUC7L2 MRPS33 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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