LUC7L2-ETV1 Fusion FISH Probe
The LUC7L2-ETV1 Fusion FISH Probe is used to confirm a fusion of the LUC7L2 and ETV1 genes. The fusion of the LUC7L2 and ETV1 genes has been associated with Prostate Adenocarcinoma, and Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| LUC7L2-ETV1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| LUC7L2-ETV1-20-RERE | 20 (40 μL) | 200 μL |
|
|
| LUC7L2-ETV1-20-REOR | 20 (40 μL) | 200 μL |
|
|
| LUC7L2-ETV1-20-REGO | 20 (40 μL) | 200 μL |
|
|
| LUC7L2-ETV1-20-REGR | 20 (40 μL) | 200 μL |
|
|
| LUC7L2-ETV1-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| LUC7L2-ETV1-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| LUC7L2-ETV1-20-OROR | 20 (40 μL) | 200 μL |
|
|
| LUC7L2-ETV1-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| LUC7L2-ETV1-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| LUC7L2-ETV1-20-GORE | 20 (40 μL) | 200 μL |
|
|
| LUC7L2-ETV1-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| LUC7L2-ETV1-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| LUC7L2-ETV1-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| LUC7L2-ETV1-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| LUC7L2-ETV1-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| LUC7L2-ETV1-20-GROR | 20 (40 μL) | 200 μL |
|
|
| LUC7L2-ETV1-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| LUC7L2-ETV1-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| LUC7L2-ETV1-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| LUC7L2-ETV1-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| LUC7L2-ETV1-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| LUC7L2-ETV1-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| LUC7L2-ETV1-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| LUC7L2-ETV1-20-AQAQ | 20 (40 μL) | 200 μL |
|
ETV1 Gene Summary
This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2016]
Gene Name: ETS Variant 1
Chromosome: CHR7: 13930855 -14031050
Locus: 7p21.2
LUC7L2 Gene Summary
This gene encodes a protein that contains a C2H2-type zinc finger, coiled-coil region and arginine, serine-rich (RS) domain. A similar protein in mouse interacts with sodium channel modifier 1, and the encoded protein may be involved in the recognition of non-consensus splice donor sites in association with the U1 snRNP spliceosomal subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Gene Name: LUC7 Like 2, Pre-mRNA Splicing Factor
Chromosome: CHR7: 139044633 -139108200
Locus: 7q34
Gene Diseases
The LUC7L2 ETV1 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Prostate Adenocarcinoma |
| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|