LUC7L-AXIN1 Fusion FISH Probe
The LUC7L-AXIN1 Fusion FISH Probe is used to confirm a fusion of the LUC7L and AXIN1 genes. The fusion of the LUC7L and AXIN1 genes has been associated with Ovarian Serous Cystadenocarcinoma, Lung Squamous Cell Carcinoma, and Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LUC7L-AXIN1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LUC7L-AXIN1-20-RERE | 20 (40 μL) | 200 μL |
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| LUC7L-AXIN1-20-REOR | 20 (40 μL) | 200 μL |
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| LUC7L-AXIN1-20-REGO | 20 (40 μL) | 200 μL |
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| LUC7L-AXIN1-20-REGR | 20 (40 μL) | 200 μL |
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| LUC7L-AXIN1-20-REAQ | 20 (40 μL) | 200 μL |
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| LUC7L-AXIN1-20-ORRE | 20 (40 μL) | 200 μL |
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| LUC7L-AXIN1-20-OROR | 20 (40 μL) | 200 μL |
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| LUC7L-AXIN1-20-ORGO | 20 (40 μL) | 200 μL |
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| LUC7L-AXIN1-20-ORAQ | 20 (40 μL) | 200 μL |
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| LUC7L-AXIN1-20-GORE | 20 (40 μL) | 200 μL |
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| LUC7L-AXIN1-20-GOOR | 20 (40 μL) | 200 μL |
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| LUC7L-AXIN1-20-GOGO | 20 (40 μL) | 200 μL |
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| LUC7L-AXIN1-20-GOGR | 20 (40 μL) | 200 μL |
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| LUC7L-AXIN1-20-GOAQ | 20 (40 μL) | 200 μL |
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| LUC7L-AXIN1-20-GRRE | 20 (40 μL) | 200 μL |
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| LUC7L-AXIN1-20-GROR | 20 (40 μL) | 200 μL |
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| LUC7L-AXIN1-20-GRGO | 20 (40 μL) | 200 μL |
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| LUC7L-AXIN1-20-GRGR | 20 (40 μL) | 200 μL |
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| LUC7L-AXIN1-20-GRAQ | 20 (40 μL) | 200 μL |
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| LUC7L-AXIN1-20-AQRE | 20 (40 μL) | 200 μL |
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| LUC7L-AXIN1-20-AQOR | 20 (40 μL) | 200 μL |
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| LUC7L-AXIN1-20-AQGO | 20 (40 μL) | 200 μL |
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| LUC7L-AXIN1-20-AQGR | 20 (40 μL) | 200 μL |
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| LUC7L-AXIN1-20-AQAQ | 20 (40 μL) | 200 μL |
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AXIN1 Gene Summary
This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Gene Name: Axin 1
Chromosome: CHR16: 337439 -402676
Locus: 16p13.3
LUC7L Gene Summary
The LUC7L gene may represent a mammalian heterochromatic gene, encoding a putative RNA-binding protein similar to the yeast Luc7p subunit of the U1 snRNP splicing complex that is normally required for 5-prime splice site selection (Tufarelli et al., 2001 [PubMed 11170747]).[supplied by OMIM, Mar 2008]
Gene Name: LUC7 Like
Chromosome: CHR16: 238969 -279449
Locus: 16p13.3
Gene Diseases
The LUC7L AXIN1 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
| Lung Squamous Cell Carcinoma |
| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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