LTF-SEC63 Fusion FISH Probe
The LTF-SEC63 Fusion FISH Probe is used to confirm a fusion of the LTF and SEC63 genes. The fusion of the LTF and SEC63 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LTF-SEC63-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LTF-SEC63-20-RERE | 20 (40 μL) | 200 μL |
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| LTF-SEC63-20-REOR | 20 (40 μL) | 200 μL |
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| LTF-SEC63-20-REGO | 20 (40 μL) | 200 μL |
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| LTF-SEC63-20-REGR | 20 (40 μL) | 200 μL |
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| LTF-SEC63-20-REAQ | 20 (40 μL) | 200 μL |
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| LTF-SEC63-20-ORRE | 20 (40 μL) | 200 μL |
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| LTF-SEC63-20-OROR | 20 (40 μL) | 200 μL |
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| LTF-SEC63-20-ORGO | 20 (40 μL) | 200 μL |
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| LTF-SEC63-20-ORAQ | 20 (40 μL) | 200 μL |
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| LTF-SEC63-20-GORE | 20 (40 μL) | 200 μL |
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| LTF-SEC63-20-GOOR | 20 (40 μL) | 200 μL |
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| LTF-SEC63-20-GOGO | 20 (40 μL) | 200 μL |
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| LTF-SEC63-20-GOGR | 20 (40 μL) | 200 μL |
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| LTF-SEC63-20-GOAQ | 20 (40 μL) | 200 μL |
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| LTF-SEC63-20-GRRE | 20 (40 μL) | 200 μL |
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| LTF-SEC63-20-GROR | 20 (40 μL) | 200 μL |
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| LTF-SEC63-20-GRGO | 20 (40 μL) | 200 μL |
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| LTF-SEC63-20-GRGR | 20 (40 μL) | 200 μL |
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| LTF-SEC63-20-GRAQ | 20 (40 μL) | 200 μL |
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| LTF-SEC63-20-AQRE | 20 (40 μL) | 200 μL |
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| LTF-SEC63-20-AQOR | 20 (40 μL) | 200 μL |
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| LTF-SEC63-20-AQGO | 20 (40 μL) | 200 μL |
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| LTF-SEC63-20-AQGR | 20 (40 μL) | 200 μL |
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| LTF-SEC63-20-AQAQ | 20 (40 μL) | 200 μL |
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LTF Gene Summary
This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Antimicrobial, antiviral, antifungal and antiparasitic activity has been found for this protein and its peptides. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Gene Name: Lactotransferrin
Chromosome: CHR3: 46477495 -46506598
Locus: 3p21.31
SEC63 Gene Summary
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]
Gene Name: SEC63 Homolog, Protein Translocation Regulator
Chromosome: CHR6: 108188959 -108279482
Locus: 6q21
Gene Diseases
The LTF SEC63 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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