LTF-CFB Fusion FISH Probe
The LTF-CFB Fusion FISH Probe is used to confirm a fusion of the LTF and CFB genes. The fusion of the LTF and CFB genes has been associated with Prostate Adenocarcinoma, and Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LTF-CFB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LTF-CFB-20-RERE | 20 (40 μL) | 200 μL |
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| LTF-CFB-20-REOR | 20 (40 μL) | 200 μL |
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| LTF-CFB-20-REGO | 20 (40 μL) | 200 μL |
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| LTF-CFB-20-REGR | 20 (40 μL) | 200 μL |
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| LTF-CFB-20-REAQ | 20 (40 μL) | 200 μL |
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| LTF-CFB-20-ORRE | 20 (40 μL) | 200 μL |
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| LTF-CFB-20-OROR | 20 (40 μL) | 200 μL |
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| LTF-CFB-20-ORGO | 20 (40 μL) | 200 μL |
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| LTF-CFB-20-ORAQ | 20 (40 μL) | 200 μL |
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| LTF-CFB-20-GORE | 20 (40 μL) | 200 μL |
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| LTF-CFB-20-GOOR | 20 (40 μL) | 200 μL |
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| LTF-CFB-20-GOGO | 20 (40 μL) | 200 μL |
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| LTF-CFB-20-GOGR | 20 (40 μL) | 200 μL |
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| LTF-CFB-20-GOAQ | 20 (40 μL) | 200 μL |
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| LTF-CFB-20-GRRE | 20 (40 μL) | 200 μL |
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| LTF-CFB-20-GROR | 20 (40 μL) | 200 μL |
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| LTF-CFB-20-GRGO | 20 (40 μL) | 200 μL |
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| LTF-CFB-20-GRGR | 20 (40 μL) | 200 μL |
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| LTF-CFB-20-GRAQ | 20 (40 μL) | 200 μL |
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| LTF-CFB-20-AQRE | 20 (40 μL) | 200 μL |
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| LTF-CFB-20-AQOR | 20 (40 μL) | 200 μL |
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| LTF-CFB-20-AQGO | 20 (40 μL) | 200 μL |
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| LTF-CFB-20-AQGR | 20 (40 μL) | 200 μL |
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| LTF-CFB-20-AQAQ | 20 (40 μL) | 200 μL |
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CFB Gene Summary
This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008]
Gene Name: Complement Factor B
Chromosome: CHR6_dbb_hap3: 3199308 -3205449
Locus: 6p21.33
LTF Gene Summary
This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Antimicrobial, antiviral, antifungal and antiparasitic activity has been found for this protein and its peptides. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Gene Name: Lactotransferrin
Chromosome: CHR3: 46477495 -46506598
Locus: 3p21.31
Gene Diseases
The LTF CFB Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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