LTF-C7 Fusion FISH Probe
The LTF-C7 Fusion FISH Probe is used to confirm a fusion of the LTF and C7 genes. The fusion of the LTF and C7 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LTF-C7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LTF-C7-20-RERE | 20 (40 μL) | 200 μL |
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| LTF-C7-20-REOR | 20 (40 μL) | 200 μL |
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| LTF-C7-20-REGO | 20 (40 μL) | 200 μL |
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| LTF-C7-20-REGR | 20 (40 μL) | 200 μL |
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| LTF-C7-20-REAQ | 20 (40 μL) | 200 μL |
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| LTF-C7-20-ORRE | 20 (40 μL) | 200 μL |
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| LTF-C7-20-OROR | 20 (40 μL) | 200 μL |
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| LTF-C7-20-ORGO | 20 (40 μL) | 200 μL |
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| LTF-C7-20-ORAQ | 20 (40 μL) | 200 μL |
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| LTF-C7-20-GORE | 20 (40 μL) | 200 μL |
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| LTF-C7-20-GOOR | 20 (40 μL) | 200 μL |
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| LTF-C7-20-GOGO | 20 (40 μL) | 200 μL |
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| LTF-C7-20-GOGR | 20 (40 μL) | 200 μL |
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| LTF-C7-20-GOAQ | 20 (40 μL) | 200 μL |
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| LTF-C7-20-GRRE | 20 (40 μL) | 200 μL |
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| LTF-C7-20-GROR | 20 (40 μL) | 200 μL |
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| LTF-C7-20-GRGO | 20 (40 μL) | 200 μL |
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| LTF-C7-20-GRGR | 20 (40 μL) | 200 μL |
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| LTF-C7-20-GRAQ | 20 (40 μL) | 200 μL |
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| LTF-C7-20-AQRE | 20 (40 μL) | 200 μL |
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| LTF-C7-20-AQOR | 20 (40 μL) | 200 μL |
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| LTF-C7-20-AQGO | 20 (40 μL) | 200 μL |
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| LTF-C7-20-AQGR | 20 (40 μL) | 200 μL |
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| LTF-C7-20-AQAQ | 20 (40 μL) | 200 μL |
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C7 Gene Summary
This gene encodes a serum glycoprotein that forms a membrane attack complex together with complement components C5b, C6, C8, and C9 as part of the terminal complement pathway of the innate immune system. The protein encoded by this gene contains a cholesterol-dependent cytolysin/membrane attack complex/perforin-like (CDC/MACPF) domain and belongs to a large family of structurally related molecules that form pores involved in host immunity and bacterial pathogenesis. This protein initiates membrane attack complex formation by binding the C5b-C6 subcomplex and inserts into the phospholipid bilayer, serving as a membrane anchor. Mutations in this gene are associated with a rare disorder called C7 deficiency. [provided by RefSeq, Nov 2016]
Gene Name: Complement C7
Chromosome: CHR5: 40909598 -40983042
Locus: 5p13.1
LTF Gene Summary
This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Antimicrobial, antiviral, antifungal and antiparasitic activity has been found for this protein and its peptides. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Gene Name: Lactotransferrin
Chromosome: CHR3: 46477495 -46506598
Locus: 3p21.31
Gene Diseases
The LTF C7 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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