LTBP4-SUPT16H Fusion FISH Probe
The LTBP4-SUPT16H Fusion FISH Probe is used to confirm a fusion of the LTBP4 and SUPT16H genes. The fusion of the LTBP4 and SUPT16H genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LTBP4-SUPT16H-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LTBP4-SUPT16H-20-RERE | 20 (40 μL) | 200 μL |
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| LTBP4-SUPT16H-20-REOR | 20 (40 μL) | 200 μL |
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| LTBP4-SUPT16H-20-REGO | 20 (40 μL) | 200 μL |
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| LTBP4-SUPT16H-20-REGR | 20 (40 μL) | 200 μL |
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| LTBP4-SUPT16H-20-REAQ | 20 (40 μL) | 200 μL |
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| LTBP4-SUPT16H-20-ORRE | 20 (40 μL) | 200 μL |
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| LTBP4-SUPT16H-20-OROR | 20 (40 μL) | 200 μL |
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| LTBP4-SUPT16H-20-ORGO | 20 (40 μL) | 200 μL |
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| LTBP4-SUPT16H-20-ORAQ | 20 (40 μL) | 200 μL |
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| LTBP4-SUPT16H-20-GORE | 20 (40 μL) | 200 μL |
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| LTBP4-SUPT16H-20-GOOR | 20 (40 μL) | 200 μL |
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| LTBP4-SUPT16H-20-GOGO | 20 (40 μL) | 200 μL |
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| LTBP4-SUPT16H-20-GOGR | 20 (40 μL) | 200 μL |
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| LTBP4-SUPT16H-20-GOAQ | 20 (40 μL) | 200 μL |
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| LTBP4-SUPT16H-20-GRRE | 20 (40 μL) | 200 μL |
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| LTBP4-SUPT16H-20-GROR | 20 (40 μL) | 200 μL |
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| LTBP4-SUPT16H-20-GRGO | 20 (40 μL) | 200 μL |
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| LTBP4-SUPT16H-20-GRGR | 20 (40 μL) | 200 μL |
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| LTBP4-SUPT16H-20-GRAQ | 20 (40 μL) | 200 μL |
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| LTBP4-SUPT16H-20-AQRE | 20 (40 μL) | 200 μL |
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| LTBP4-SUPT16H-20-AQOR | 20 (40 μL) | 200 μL |
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| LTBP4-SUPT16H-20-AQGO | 20 (40 μL) | 200 μL |
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| LTBP4-SUPT16H-20-AQGR | 20 (40 μL) | 200 μL |
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| LTBP4-SUPT16H-20-AQAQ | 20 (40 μL) | 200 μL |
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LTBP4 Gene Summary
The protein encoded by this gene binds transforming growth factor beta (TGFB) as it is secreted and targeted to the extracellular matrix. TGFB is biologically latent after secretion and insertion into the extracellular matrix, and sheds TGFB and other proteins upon activation. Defects in this gene may be a cause of cutis laxa and severe pulmonary, gastrointestinal, and urinary abnormalities. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
Gene Name: Latent Transforming Growth Factor Beta Binding Protein 4
Chromosome: CHR19: 41099071 -41135725
Locus: 19q13.2
SUPT16H Gene Summary
Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]
Gene Name: SPT16 Homolog, Facilitates Chromatin Remodeling Subunit
Chromosome: CHR14: 21819630 -21852425
Locus: 14q11.2
Gene Diseases
The LTBP4 SUPT16H Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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