LTBP1-PLB1 Fusion FISH Probe
The LTBP1-PLB1 Fusion FISH Probe is used to confirm a fusion of the LTBP1 and PLB1 genes. The fusion of the LTBP1 and PLB1 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LTBP1-PLB1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LTBP1-PLB1-20-RERE | 20 (40 μL) | 200 μL |
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| LTBP1-PLB1-20-REOR | 20 (40 μL) | 200 μL |
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| LTBP1-PLB1-20-REGO | 20 (40 μL) | 200 μL |
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| LTBP1-PLB1-20-REGR | 20 (40 μL) | 200 μL |
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| LTBP1-PLB1-20-REAQ | 20 (40 μL) | 200 μL |
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| LTBP1-PLB1-20-ORRE | 20 (40 μL) | 200 μL |
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| LTBP1-PLB1-20-OROR | 20 (40 μL) | 200 μL |
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| LTBP1-PLB1-20-ORGO | 20 (40 μL) | 200 μL |
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| LTBP1-PLB1-20-ORAQ | 20 (40 μL) | 200 μL |
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| LTBP1-PLB1-20-GORE | 20 (40 μL) | 200 μL |
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| LTBP1-PLB1-20-GOOR | 20 (40 μL) | 200 μL |
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| LTBP1-PLB1-20-GOGO | 20 (40 μL) | 200 μL |
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| LTBP1-PLB1-20-GOGR | 20 (40 μL) | 200 μL |
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| LTBP1-PLB1-20-GOAQ | 20 (40 μL) | 200 μL |
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| LTBP1-PLB1-20-GRRE | 20 (40 μL) | 200 μL |
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| LTBP1-PLB1-20-GROR | 20 (40 μL) | 200 μL |
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| LTBP1-PLB1-20-GRGO | 20 (40 μL) | 200 μL |
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| LTBP1-PLB1-20-GRGR | 20 (40 μL) | 200 μL |
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| LTBP1-PLB1-20-GRAQ | 20 (40 μL) | 200 μL |
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| LTBP1-PLB1-20-AQRE | 20 (40 μL) | 200 μL |
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| LTBP1-PLB1-20-AQOR | 20 (40 μL) | 200 μL |
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| LTBP1-PLB1-20-AQGO | 20 (40 μL) | 200 μL |
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| LTBP1-PLB1-20-AQGR | 20 (40 μL) | 200 μL |
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| LTBP1-PLB1-20-AQAQ | 20 (40 μL) | 200 μL |
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LTBP1 Gene Summary
The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Latent Transforming Growth Factor Beta Binding Protein 1
Chromosome: CHR2: 33172368 -33624575
Locus: 2p22.3
PLB1 Gene Summary
This gene encodes a membrane-associated phospholipase that displays lysophospholipase and phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids. In addition, it displays lipase and retinyl ester hydrolase activities. The encoded protein is highly conserved and is composed of a large, glycosylated extracellular domain composed of four tandem homologous domains, followed by a hydrophobic segment that anchors the enzyme to the membrane and a short C-terminal cytoplasmic tail. This gene has been identified as a candidate rheumatoid arthritis risk gene. [provided by RefSeq, Jul 2016]
Gene Name: Phospholipase B1
Chromosome: CHR2: 28718937 -28866653
Locus: 2p23.2
Gene Diseases
The LTBP1 PLB1 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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