LRRK2-GXYLT1 Fusion FISH Probe
The LRRK2-GXYLT1 Fusion FISH Probe is used to confirm a fusion of the LRRK2 and GXYLT1 genes. The fusion of the LRRK2 and GXYLT1 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LRRK2-GXYLT1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LRRK2-GXYLT1-20-RERE | 20 (40 μL) | 200 μL |
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| LRRK2-GXYLT1-20-REOR | 20 (40 μL) | 200 μL |
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| LRRK2-GXYLT1-20-REGO | 20 (40 μL) | 200 μL |
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| LRRK2-GXYLT1-20-REGR | 20 (40 μL) | 200 μL |
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| LRRK2-GXYLT1-20-REAQ | 20 (40 μL) | 200 μL |
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| LRRK2-GXYLT1-20-ORRE | 20 (40 μL) | 200 μL |
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| LRRK2-GXYLT1-20-OROR | 20 (40 μL) | 200 μL |
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| LRRK2-GXYLT1-20-ORGO | 20 (40 μL) | 200 μL |
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| LRRK2-GXYLT1-20-ORAQ | 20 (40 μL) | 200 μL |
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| LRRK2-GXYLT1-20-GORE | 20 (40 μL) | 200 μL |
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| LRRK2-GXYLT1-20-GOOR | 20 (40 μL) | 200 μL |
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| LRRK2-GXYLT1-20-GOGO | 20 (40 μL) | 200 μL |
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| LRRK2-GXYLT1-20-GOGR | 20 (40 μL) | 200 μL |
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| LRRK2-GXYLT1-20-GOAQ | 20 (40 μL) | 200 μL |
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| LRRK2-GXYLT1-20-GRRE | 20 (40 μL) | 200 μL |
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| LRRK2-GXYLT1-20-GROR | 20 (40 μL) | 200 μL |
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| LRRK2-GXYLT1-20-GRGO | 20 (40 μL) | 200 μL |
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| LRRK2-GXYLT1-20-GRGR | 20 (40 μL) | 200 μL |
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| LRRK2-GXYLT1-20-GRAQ | 20 (40 μL) | 200 μL |
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| LRRK2-GXYLT1-20-AQRE | 20 (40 μL) | 200 μL |
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| LRRK2-GXYLT1-20-AQOR | 20 (40 μL) | 200 μL |
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| LRRK2-GXYLT1-20-AQGO | 20 (40 μL) | 200 μL |
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| LRRK2-GXYLT1-20-AQGR | 20 (40 μL) | 200 μL |
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| LRRK2-GXYLT1-20-AQAQ | 20 (40 μL) | 200 μL |
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LRRK2 Gene Summary
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]
Gene Name: Leucine Rich Repeat Kinase 2
Chromosome: CHR12: 40618812 -40763086
Locus: 12q12
GXYLT1 Gene Summary
GXYLT1 is a xylosyltransferase (EC 2.4.2.-) that adds the first xylose to O-glucose-modified residues in the epidermal growth factor (EGF; MIM 131530) repeats of proteins such as NOTCH1 (MIM 190198) (Sethi et al., 2010 [PubMed 19940119]).[supplied by OMIM, Mar 2010]
Gene Name: Glucoside Xylosyltransferase 1
Chromosome: CHR12: 42475647 -42538673
Locus: 12q12
Gene Diseases
The LRRK2 GXYLT1 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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