LRRFIP2-EPHA3 Fusion FISH Probe
The LRRFIP2-EPHA3 Fusion FISH Probe is used to confirm a fusion of the LRRFIP2 and EPHA3 genes. The fusion of the LRRFIP2 and EPHA3 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LRRFIP2-EPHA3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LRRFIP2-EPHA3-20-RERE | 20 (40 μL) | 200 μL |
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| LRRFIP2-EPHA3-20-REOR | 20 (40 μL) | 200 μL |
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| LRRFIP2-EPHA3-20-REGO | 20 (40 μL) | 200 μL |
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| LRRFIP2-EPHA3-20-REGR | 20 (40 μL) | 200 μL |
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| LRRFIP2-EPHA3-20-REAQ | 20 (40 μL) | 200 μL |
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| LRRFIP2-EPHA3-20-ORRE | 20 (40 μL) | 200 μL |
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| LRRFIP2-EPHA3-20-OROR | 20 (40 μL) | 200 μL |
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| LRRFIP2-EPHA3-20-ORGO | 20 (40 μL) | 200 μL |
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| LRRFIP2-EPHA3-20-ORAQ | 20 (40 μL) | 200 μL |
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| LRRFIP2-EPHA3-20-GORE | 20 (40 μL) | 200 μL |
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| LRRFIP2-EPHA3-20-GOOR | 20 (40 μL) | 200 μL |
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| LRRFIP2-EPHA3-20-GOGO | 20 (40 μL) | 200 μL |
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| LRRFIP2-EPHA3-20-GOGR | 20 (40 μL) | 200 μL |
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| LRRFIP2-EPHA3-20-GOAQ | 20 (40 μL) | 200 μL |
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| LRRFIP2-EPHA3-20-GRRE | 20 (40 μL) | 200 μL |
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| LRRFIP2-EPHA3-20-GROR | 20 (40 μL) | 200 μL |
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| LRRFIP2-EPHA3-20-GRGO | 20 (40 μL) | 200 μL |
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| LRRFIP2-EPHA3-20-GRGR | 20 (40 μL) | 200 μL |
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| LRRFIP2-EPHA3-20-GRAQ | 20 (40 μL) | 200 μL |
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| LRRFIP2-EPHA3-20-AQRE | 20 (40 μL) | 200 μL |
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| LRRFIP2-EPHA3-20-AQOR | 20 (40 μL) | 200 μL |
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| LRRFIP2-EPHA3-20-AQGO | 20 (40 μL) | 200 μL |
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| LRRFIP2-EPHA3-20-AQGR | 20 (40 μL) | 200 μL |
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| LRRFIP2-EPHA3-20-AQAQ | 20 (40 μL) | 200 μL |
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EPHA3 Gene Summary
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: EPH Receptor A3
Chromosome: CHR3: 89156673 -89531284
Locus: 3p11.1
LRRFIP2 Gene Summary
The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex. [provided by RefSeq, Jan 2017]
Gene Name: LRR Binding FLII Interacting Protein 2
Chromosome: CHR3: 37094116 -37217851
Locus: 3p22.2
Gene Diseases
The LRRFIP2 EPHA3 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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