LRRC8A-MEN1 Fusion FISH Probe
The LRRC8A-MEN1 Fusion FISH Probe is used to confirm a fusion of the LRRC8A and MEN1 genes. The fusion of the LRRC8A and MEN1 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LRRC8A-MEN1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LRRC8A-MEN1-20-RERE | 20 (40 μL) | 200 μL |
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| LRRC8A-MEN1-20-REOR | 20 (40 μL) | 200 μL |
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| LRRC8A-MEN1-20-REGO | 20 (40 μL) | 200 μL |
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| LRRC8A-MEN1-20-REGR | 20 (40 μL) | 200 μL |
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| LRRC8A-MEN1-20-REAQ | 20 (40 μL) | 200 μL |
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| LRRC8A-MEN1-20-ORRE | 20 (40 μL) | 200 μL |
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| LRRC8A-MEN1-20-OROR | 20 (40 μL) | 200 μL |
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| LRRC8A-MEN1-20-ORGO | 20 (40 μL) | 200 μL |
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| LRRC8A-MEN1-20-ORAQ | 20 (40 μL) | 200 μL |
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| LRRC8A-MEN1-20-GORE | 20 (40 μL) | 200 μL |
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| LRRC8A-MEN1-20-GOOR | 20 (40 μL) | 200 μL |
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| LRRC8A-MEN1-20-GOGO | 20 (40 μL) | 200 μL |
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| LRRC8A-MEN1-20-GOGR | 20 (40 μL) | 200 μL |
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| LRRC8A-MEN1-20-GOAQ | 20 (40 μL) | 200 μL |
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| LRRC8A-MEN1-20-GRRE | 20 (40 μL) | 200 μL |
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| LRRC8A-MEN1-20-GROR | 20 (40 μL) | 200 μL |
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| LRRC8A-MEN1-20-GRGO | 20 (40 μL) | 200 μL |
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| LRRC8A-MEN1-20-GRGR | 20 (40 μL) | 200 μL |
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| LRRC8A-MEN1-20-GRAQ | 20 (40 μL) | 200 μL |
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| LRRC8A-MEN1-20-AQRE | 20 (40 μL) | 200 μL |
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| LRRC8A-MEN1-20-AQOR | 20 (40 μL) | 200 μL |
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| LRRC8A-MEN1-20-AQGO | 20 (40 μL) | 200 μL |
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| LRRC8A-MEN1-20-AQGR | 20 (40 μL) | 200 μL |
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| LRRC8A-MEN1-20-AQAQ | 20 (40 μL) | 200 μL |
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MEN1 Gene Summary
This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]
Gene Name: Menin 1
Chromosome: CHR11: 64570985 -64578766
Locus: 11q13.1
LRRC8A Gene Summary
This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. This family member is a putative four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Leucine Rich Repeat Containing 8 VRAC Subunit A
Chromosome: CHR9: 131644390 -131680317
Locus: 9q34.11
Gene Diseases
The LRRC8A MEN1 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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