LRP8-RAD51C Fusion FISH Probe
The LRP8-RAD51C Fusion FISH Probe is used to confirm a fusion of the LRP8 and RAD51C genes. The fusion of the LRP8 and RAD51C genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LRP8-RAD51C-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LRP8-RAD51C-20-RERE | 20 (40 μL) | 200 μL |
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| LRP8-RAD51C-20-REOR | 20 (40 μL) | 200 μL |
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| LRP8-RAD51C-20-REGO | 20 (40 μL) | 200 μL |
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| LRP8-RAD51C-20-REGR | 20 (40 μL) | 200 μL |
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| LRP8-RAD51C-20-REAQ | 20 (40 μL) | 200 μL |
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| LRP8-RAD51C-20-ORRE | 20 (40 μL) | 200 μL |
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| LRP8-RAD51C-20-OROR | 20 (40 μL) | 200 μL |
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| LRP8-RAD51C-20-ORGO | 20 (40 μL) | 200 μL |
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| LRP8-RAD51C-20-ORAQ | 20 (40 μL) | 200 μL |
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| LRP8-RAD51C-20-GORE | 20 (40 μL) | 200 μL |
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| LRP8-RAD51C-20-GOOR | 20 (40 μL) | 200 μL |
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| LRP8-RAD51C-20-GOGO | 20 (40 μL) | 200 μL |
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| LRP8-RAD51C-20-GOGR | 20 (40 μL) | 200 μL |
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| LRP8-RAD51C-20-GOAQ | 20 (40 μL) | 200 μL |
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| LRP8-RAD51C-20-GRRE | 20 (40 μL) | 200 μL |
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| LRP8-RAD51C-20-GROR | 20 (40 μL) | 200 μL |
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| LRP8-RAD51C-20-GRGO | 20 (40 μL) | 200 μL |
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| LRP8-RAD51C-20-GRGR | 20 (40 μL) | 200 μL |
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| LRP8-RAD51C-20-GRAQ | 20 (40 μL) | 200 μL |
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| LRP8-RAD51C-20-AQRE | 20 (40 μL) | 200 μL |
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| LRP8-RAD51C-20-AQOR | 20 (40 μL) | 200 μL |
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| LRP8-RAD51C-20-AQGO | 20 (40 μL) | 200 μL |
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| LRP8-RAD51C-20-AQGR | 20 (40 μL) | 200 μL |
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| LRP8-RAD51C-20-AQAQ | 20 (40 μL) | 200 μL |
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RAD51C Gene Summary
This gene is a member of the RAD51 family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51 and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Name: RAD51 Paralog C
Chromosome: CHR17: 56769962 -56811692
Locus: 17q22
LRP8 Gene Summary
This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011]
Gene Name: LDL Receptor Related Protein 8
Chromosome: CHR1: 53708040 -53793821
Locus: 1p32.3
Gene Diseases
The LRP8 RAD51C Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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