LRP6-PTPRO Fusion FISH Probe
The LRP6-PTPRO Fusion FISH Probe is used to confirm a fusion of the LRP6 and PTPRO genes. The fusion of the LRP6 and PTPRO genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| LRP6-PTPRO-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| LRP6-PTPRO-20-RERE | 20 (40 μL) | 200 μL |
|
|
| LRP6-PTPRO-20-REOR | 20 (40 μL) | 200 μL |
|
|
| LRP6-PTPRO-20-REGO | 20 (40 μL) | 200 μL |
|
|
| LRP6-PTPRO-20-REGR | 20 (40 μL) | 200 μL |
|
|
| LRP6-PTPRO-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| LRP6-PTPRO-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| LRP6-PTPRO-20-OROR | 20 (40 μL) | 200 μL |
|
|
| LRP6-PTPRO-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| LRP6-PTPRO-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| LRP6-PTPRO-20-GORE | 20 (40 μL) | 200 μL |
|
|
| LRP6-PTPRO-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| LRP6-PTPRO-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| LRP6-PTPRO-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| LRP6-PTPRO-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| LRP6-PTPRO-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| LRP6-PTPRO-20-GROR | 20 (40 μL) | 200 μL |
|
|
| LRP6-PTPRO-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| LRP6-PTPRO-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| LRP6-PTPRO-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| LRP6-PTPRO-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| LRP6-PTPRO-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| LRP6-PTPRO-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| LRP6-PTPRO-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| LRP6-PTPRO-20-AQAQ | 20 (40 μL) | 200 μL |
|
LRP6 Gene Summary
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]
Gene Name: LDL Receptor Related Protein 6
Chromosome: CHR12: 12268960 -12419811
Locus: 12p13.2
PTPRO Gene Summary
This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. [provided by RefSeq, May 2011]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type O
Chromosome: CHR12: 15475190 -15751265
Locus: 12p13-p12
Gene Diseases
The LRP6 PTPRO Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|