LRP6-MANSC1 Fusion FISH Probe
The LRP6-MANSC1 Fusion FISH Probe is used to confirm a fusion of the LRP6 and MANSC1 genes. The fusion of the LRP6 and MANSC1 genes has been associated with Liver Hepatocellular Carcinoma, and Testicular Germ Cell Tumors. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LRP6-MANSC1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LRP6-MANSC1-20-RERE | 20 (40 μL) | 200 μL |
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| LRP6-MANSC1-20-REOR | 20 (40 μL) | 200 μL |
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| LRP6-MANSC1-20-REGO | 20 (40 μL) | 200 μL |
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| LRP6-MANSC1-20-REGR | 20 (40 μL) | 200 μL |
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| LRP6-MANSC1-20-REAQ | 20 (40 μL) | 200 μL |
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| LRP6-MANSC1-20-ORRE | 20 (40 μL) | 200 μL |
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| LRP6-MANSC1-20-OROR | 20 (40 μL) | 200 μL |
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| LRP6-MANSC1-20-ORGO | 20 (40 μL) | 200 μL |
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| LRP6-MANSC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| LRP6-MANSC1-20-GORE | 20 (40 μL) | 200 μL |
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| LRP6-MANSC1-20-GOOR | 20 (40 μL) | 200 μL |
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| LRP6-MANSC1-20-GOGO | 20 (40 μL) | 200 μL |
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| LRP6-MANSC1-20-GOGR | 20 (40 μL) | 200 μL |
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| LRP6-MANSC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| LRP6-MANSC1-20-GRRE | 20 (40 μL) | 200 μL |
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| LRP6-MANSC1-20-GROR | 20 (40 μL) | 200 μL |
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| LRP6-MANSC1-20-GRGO | 20 (40 μL) | 200 μL |
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| LRP6-MANSC1-20-GRGR | 20 (40 μL) | 200 μL |
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| LRP6-MANSC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| LRP6-MANSC1-20-AQRE | 20 (40 μL) | 200 μL |
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| LRP6-MANSC1-20-AQOR | 20 (40 μL) | 200 μL |
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| LRP6-MANSC1-20-AQGO | 20 (40 μL) | 200 μL |
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| LRP6-MANSC1-20-AQGR | 20 (40 μL) | 200 μL |
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| LRP6-MANSC1-20-AQAQ | 20 (40 μL) | 200 μL |
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LRP6 Gene Summary
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]
Gene Name: LDL Receptor Related Protein 6
Chromosome: CHR12: 12268960 -12419811
Locus: 12p13.2
MANSC1 Gene Summary
The MANSC Domain Containing 1 (MANSC1) gene is located on chr12 :12482217-12503169 at 12p13.2.
Gene Name: MANSC Domain Containing 1
Chromosome: CHR12: 12482217 -12503169
Locus: 12p13.2
Gene Diseases
The LRP6 MANSC1 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
| Testicular Germ Cell Tumors |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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