LRP5-UVRAG Fusion FISH Probe
The LRP5-UVRAG Fusion FISH Probe is used to confirm a fusion of the LRP5 and UVRAG genes. The fusion of the LRP5 and UVRAG genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LRP5-UVRAG-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LRP5-UVRAG-20-RERE | 20 (40 μL) | 200 μL |
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| LRP5-UVRAG-20-REOR | 20 (40 μL) | 200 μL |
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| LRP5-UVRAG-20-REGO | 20 (40 μL) | 200 μL |
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| LRP5-UVRAG-20-REGR | 20 (40 μL) | 200 μL |
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| LRP5-UVRAG-20-REAQ | 20 (40 μL) | 200 μL |
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| LRP5-UVRAG-20-ORRE | 20 (40 μL) | 200 μL |
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| LRP5-UVRAG-20-OROR | 20 (40 μL) | 200 μL |
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| LRP5-UVRAG-20-ORGO | 20 (40 μL) | 200 μL |
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| LRP5-UVRAG-20-ORAQ | 20 (40 μL) | 200 μL |
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| LRP5-UVRAG-20-GORE | 20 (40 μL) | 200 μL |
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| LRP5-UVRAG-20-GOOR | 20 (40 μL) | 200 μL |
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| LRP5-UVRAG-20-GOGO | 20 (40 μL) | 200 μL |
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| LRP5-UVRAG-20-GOGR | 20 (40 μL) | 200 μL |
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| LRP5-UVRAG-20-GOAQ | 20 (40 μL) | 200 μL |
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| LRP5-UVRAG-20-GRRE | 20 (40 μL) | 200 μL |
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| LRP5-UVRAG-20-GROR | 20 (40 μL) | 200 μL |
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| LRP5-UVRAG-20-GRGO | 20 (40 μL) | 200 μL |
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| LRP5-UVRAG-20-GRGR | 20 (40 μL) | 200 μL |
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| LRP5-UVRAG-20-GRAQ | 20 (40 μL) | 200 μL |
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| LRP5-UVRAG-20-AQRE | 20 (40 μL) | 200 μL |
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| LRP5-UVRAG-20-AQOR | 20 (40 μL) | 200 μL |
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| LRP5-UVRAG-20-AQGO | 20 (40 μL) | 200 μL |
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| LRP5-UVRAG-20-AQGR | 20 (40 μL) | 200 μL |
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| LRP5-UVRAG-20-AQAQ | 20 (40 μL) | 200 μL |
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LRP5 Gene Summary
This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Name: LDL Receptor Related Protein 5
Chromosome: CHR11: 68080107 -68216743
Locus: 11q13.2
UVRAG Gene Summary
This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008]
Gene Name: UV Radiation Resistance Associated
Chromosome: CHR11: 75526211 -75855282
Locus: 11q13.5
Gene Diseases
The LRP5 UVRAG Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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