LRP5-NOX4 Fusion FISH Probe
The LRP5-NOX4 Fusion FISH Probe is used to confirm a fusion of the LRP5 and NOX4 genes. The fusion of the LRP5 and NOX4 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LRP5-NOX4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LRP5-NOX4-20-RERE | 20 (40 μL) | 200 μL |
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| LRP5-NOX4-20-REOR | 20 (40 μL) | 200 μL |
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| LRP5-NOX4-20-REGO | 20 (40 μL) | 200 μL |
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| LRP5-NOX4-20-REGR | 20 (40 μL) | 200 μL |
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| LRP5-NOX4-20-REAQ | 20 (40 μL) | 200 μL |
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| LRP5-NOX4-20-ORRE | 20 (40 μL) | 200 μL |
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| LRP5-NOX4-20-OROR | 20 (40 μL) | 200 μL |
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| LRP5-NOX4-20-ORGO | 20 (40 μL) | 200 μL |
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| LRP5-NOX4-20-ORAQ | 20 (40 μL) | 200 μL |
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| LRP5-NOX4-20-GORE | 20 (40 μL) | 200 μL |
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| LRP5-NOX4-20-GOOR | 20 (40 μL) | 200 μL |
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| LRP5-NOX4-20-GOGO | 20 (40 μL) | 200 μL |
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| LRP5-NOX4-20-GOGR | 20 (40 μL) | 200 μL |
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| LRP5-NOX4-20-GOAQ | 20 (40 μL) | 200 μL |
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| LRP5-NOX4-20-GRRE | 20 (40 μL) | 200 μL |
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| LRP5-NOX4-20-GROR | 20 (40 μL) | 200 μL |
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| LRP5-NOX4-20-GRGO | 20 (40 μL) | 200 μL |
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| LRP5-NOX4-20-GRGR | 20 (40 μL) | 200 μL |
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| LRP5-NOX4-20-GRAQ | 20 (40 μL) | 200 μL |
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| LRP5-NOX4-20-AQRE | 20 (40 μL) | 200 μL |
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| LRP5-NOX4-20-AQOR | 20 (40 μL) | 200 μL |
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| LRP5-NOX4-20-AQGO | 20 (40 μL) | 200 μL |
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| LRP5-NOX4-20-AQGR | 20 (40 μL) | 200 μL |
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| LRP5-NOX4-20-AQAQ | 20 (40 μL) | 200 μL |
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LRP5 Gene Summary
This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Name: LDL Receptor Related Protein 5
Chromosome: CHR11: 68080107 -68216743
Locus: 11q13.2
NOX4 Gene Summary
This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]
Gene Name: NADPH Oxidase 4
Chromosome: CHR11: 89057521 -89322779
Locus: 11q14.3
Gene Diseases
The LRP5 NOX4 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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