LRP5-CLPB Fusion FISH Probe
The LRP5-CLPB Fusion FISH Probe is used to confirm a fusion of the LRP5 and CLPB genes. The fusion of the LRP5 and CLPB genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LRP5-CLPB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LRP5-CLPB-20-RERE | 20 (40 μL) | 200 μL |
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| LRP5-CLPB-20-REOR | 20 (40 μL) | 200 μL |
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| LRP5-CLPB-20-REGO | 20 (40 μL) | 200 μL |
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| LRP5-CLPB-20-REGR | 20 (40 μL) | 200 μL |
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| LRP5-CLPB-20-REAQ | 20 (40 μL) | 200 μL |
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| LRP5-CLPB-20-ORRE | 20 (40 μL) | 200 μL |
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| LRP5-CLPB-20-OROR | 20 (40 μL) | 200 μL |
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| LRP5-CLPB-20-ORGO | 20 (40 μL) | 200 μL |
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| LRP5-CLPB-20-ORAQ | 20 (40 μL) | 200 μL |
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| LRP5-CLPB-20-GORE | 20 (40 μL) | 200 μL |
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| LRP5-CLPB-20-GOOR | 20 (40 μL) | 200 μL |
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| LRP5-CLPB-20-GOGO | 20 (40 μL) | 200 μL |
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| LRP5-CLPB-20-GOGR | 20 (40 μL) | 200 μL |
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| LRP5-CLPB-20-GOAQ | 20 (40 μL) | 200 μL |
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| LRP5-CLPB-20-GRRE | 20 (40 μL) | 200 μL |
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| LRP5-CLPB-20-GROR | 20 (40 μL) | 200 μL |
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| LRP5-CLPB-20-GRGO | 20 (40 μL) | 200 μL |
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| LRP5-CLPB-20-GRGR | 20 (40 μL) | 200 μL |
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| LRP5-CLPB-20-GRAQ | 20 (40 μL) | 200 μL |
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| LRP5-CLPB-20-AQRE | 20 (40 μL) | 200 μL |
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| LRP5-CLPB-20-AQOR | 20 (40 μL) | 200 μL |
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| LRP5-CLPB-20-AQGO | 20 (40 μL) | 200 μL |
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| LRP5-CLPB-20-AQGR | 20 (40 μL) | 200 μL |
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| LRP5-CLPB-20-AQAQ | 20 (40 μL) | 200 μL |
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LRP5 Gene Summary
This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Name: LDL Receptor Related Protein 5
Chromosome: CHR11: 68080107 -68216743
Locus: 11q13.2
CLPB Gene Summary
This gene belongs to the ATP-ases associated with diverse cellular activities (AAA+) superfamily. Members of this superfamily form ring-shaped homo-hexamers and have highly conserved ATPase domains that are involved in various processes including DNA replication, protein degradation and reactivation of misfolded proteins. All members of this family hydrolyze ATP through their AAA+ domains and use the energy generated through ATP hydrolysis to exert mechanical force on their substrates. In addition to an AAA+ domain, the protein encoded by this gene contains a C-terminal D2 domain, which is characteristic of the AAA+ subfamily of Caseinolytic peptidases to which this protein belongs. It cooperates with Hsp70 in the disaggregation of protein aggregates. Allelic variants of this gene are associated with 3-methylglutaconic aciduria, which causes cataracts and neutropenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Gene Name: ClpB Homolog, Mitochondrial AAA ATPase Chaperonin
Chromosome: CHR11: 72003469 -72145568
Locus: 11q13.4
Gene Diseases
The LRP5 CLPB Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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