LRP2-FASTKD1 Fusion FISH Probe
The LRP2-FASTKD1 Fusion FISH Probe is used to confirm a fusion of the LRP2 and FASTKD1 genes. The fusion of the LRP2 and FASTKD1 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LRP2-FASTKD1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LRP2-FASTKD1-20-RERE | 20 (40 μL) | 200 μL |
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| LRP2-FASTKD1-20-REOR | 20 (40 μL) | 200 μL |
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| LRP2-FASTKD1-20-REGO | 20 (40 μL) | 200 μL |
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| LRP2-FASTKD1-20-REGR | 20 (40 μL) | 200 μL |
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| LRP2-FASTKD1-20-REAQ | 20 (40 μL) | 200 μL |
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| LRP2-FASTKD1-20-ORRE | 20 (40 μL) | 200 μL |
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| LRP2-FASTKD1-20-OROR | 20 (40 μL) | 200 μL |
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| LRP2-FASTKD1-20-ORGO | 20 (40 μL) | 200 μL |
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| LRP2-FASTKD1-20-ORAQ | 20 (40 μL) | 200 μL |
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| LRP2-FASTKD1-20-GORE | 20 (40 μL) | 200 μL |
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| LRP2-FASTKD1-20-GOOR | 20 (40 μL) | 200 μL |
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| LRP2-FASTKD1-20-GOGO | 20 (40 μL) | 200 μL |
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| LRP2-FASTKD1-20-GOGR | 20 (40 μL) | 200 μL |
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| LRP2-FASTKD1-20-GOAQ | 20 (40 μL) | 200 μL |
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| LRP2-FASTKD1-20-GRRE | 20 (40 μL) | 200 μL |
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| LRP2-FASTKD1-20-GROR | 20 (40 μL) | 200 μL |
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| LRP2-FASTKD1-20-GRGO | 20 (40 μL) | 200 μL |
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| LRP2-FASTKD1-20-GRGR | 20 (40 μL) | 200 μL |
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| LRP2-FASTKD1-20-GRAQ | 20 (40 μL) | 200 μL |
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| LRP2-FASTKD1-20-AQRE | 20 (40 μL) | 200 μL |
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| LRP2-FASTKD1-20-AQOR | 20 (40 μL) | 200 μL |
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| LRP2-FASTKD1-20-AQGO | 20 (40 μL) | 200 μL |
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| LRP2-FASTKD1-20-AQGR | 20 (40 μL) | 200 μL |
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| LRP2-FASTKD1-20-AQAQ | 20 (40 μL) | 200 μL |
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LRP2 Gene Summary
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009]
Gene Name: LDL Receptor Related Protein 2
Chromosome: CHR2: 169983618 -170219122
Locus: 2q31.1
FASTKD1 Gene Summary
The FAST Kinase Domains 1 (FASTKD1) gene is located on chr2 :170386262-170430424 at 2q31.1.
Gene Name: FAST Kinase Domains 1
Chromosome: CHR2: 170386262 -170430424
Locus: 2q31.1
Gene Diseases
The LRP2 FASTKD1 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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