LRP1B-HECW2 Fusion FISH Probe
The LRP1B-HECW2 Fusion FISH Probe is used to confirm a fusion of the LRP1B and HECW2 genes. The fusion of the LRP1B and HECW2 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LRP1B-HECW2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LRP1B-HECW2-20-RERE | 20 (40 μL) | 200 μL |
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| LRP1B-HECW2-20-REOR | 20 (40 μL) | 200 μL |
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| LRP1B-HECW2-20-REGO | 20 (40 μL) | 200 μL |
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| LRP1B-HECW2-20-REGR | 20 (40 μL) | 200 μL |
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| LRP1B-HECW2-20-REAQ | 20 (40 μL) | 200 μL |
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| LRP1B-HECW2-20-ORRE | 20 (40 μL) | 200 μL |
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| LRP1B-HECW2-20-OROR | 20 (40 μL) | 200 μL |
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| LRP1B-HECW2-20-ORGO | 20 (40 μL) | 200 μL |
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| LRP1B-HECW2-20-ORAQ | 20 (40 μL) | 200 μL |
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| LRP1B-HECW2-20-GORE | 20 (40 μL) | 200 μL |
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| LRP1B-HECW2-20-GOOR | 20 (40 μL) | 200 μL |
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| LRP1B-HECW2-20-GOGO | 20 (40 μL) | 200 μL |
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| LRP1B-HECW2-20-GOGR | 20 (40 μL) | 200 μL |
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| LRP1B-HECW2-20-GOAQ | 20 (40 μL) | 200 μL |
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| LRP1B-HECW2-20-GRRE | 20 (40 μL) | 200 μL |
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| LRP1B-HECW2-20-GROR | 20 (40 μL) | 200 μL |
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| LRP1B-HECW2-20-GRGO | 20 (40 μL) | 200 μL |
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| LRP1B-HECW2-20-GRGR | 20 (40 μL) | 200 μL |
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| LRP1B-HECW2-20-GRAQ | 20 (40 μL) | 200 μL |
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| LRP1B-HECW2-20-AQRE | 20 (40 μL) | 200 μL |
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| LRP1B-HECW2-20-AQOR | 20 (40 μL) | 200 μL |
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| LRP1B-HECW2-20-AQGO | 20 (40 μL) | 200 μL |
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| LRP1B-HECW2-20-AQGR | 20 (40 μL) | 200 μL |
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| LRP1B-HECW2-20-AQAQ | 20 (40 μL) | 200 μL |
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LRP1B Gene Summary
This gene encodes a member of the low density lipoprotein (LDL) receptor family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. Disruption of this gene has been reported in several types of cancer. [provided by RefSeq, Jun 2016]
Gene Name: LDL Receptor Related Protein 1B
Chromosome: CHR2: 140988995 -142889270
Locus: 2q22.1-q22.2
HECW2 Gene Summary
This gene encodes a member of a family of E3 ubiquitin ligases which plays an important role in the proliferation, migration and differentiation of neural crest cells as a regulator of glial cell line-derived neurotrophic factor (GDNF)/Ret signaling. This gene also plays an important role in angiogenesis through stabilization of endothelial cell-to-cell junctions as a regulator of angiomotin-like 1 stability. The encoded protein contains an N-terminal calcium/lipid-binding (C2) domain involved in membrane targeting, two-four WW domains responsible for cellular localization and substrate recognition, and a C-terminal homologous with E6-associated protein C-terminus (HECT) catalytic domain. Naturally occurring mutations in this gene are associated with neurodevelopmental delay, hypotonia, and epilepsy. The decreased expression of this gene in the aganglionic colon is associated with Hirschsprung's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Gene Name: HECT, C2 And WW Domain Containing E3 Ubiquitin Protein Ligase 2
Chromosome: CHR2: 197063976 -197457335
Locus: 2q32.3
Gene Diseases
The LRP1B HECW2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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