LRP1-XPO5 Fusion FISH Probe
The LRP1-XPO5 Fusion FISH Probe is used to confirm a fusion of the LRP1 and XPO5 genes. The fusion of the LRP1 and XPO5 genes has been associated with Glioblastoma Multiforme. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LRP1-XPO5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LRP1-XPO5-20-RERE | 20 (40 μL) | 200 μL |
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| LRP1-XPO5-20-REOR | 20 (40 μL) | 200 μL |
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| LRP1-XPO5-20-REGO | 20 (40 μL) | 200 μL |
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| LRP1-XPO5-20-REGR | 20 (40 μL) | 200 μL |
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| LRP1-XPO5-20-REAQ | 20 (40 μL) | 200 μL |
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| LRP1-XPO5-20-ORRE | 20 (40 μL) | 200 μL |
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| LRP1-XPO5-20-OROR | 20 (40 μL) | 200 μL |
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| LRP1-XPO5-20-ORGO | 20 (40 μL) | 200 μL |
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| LRP1-XPO5-20-ORAQ | 20 (40 μL) | 200 μL |
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| LRP1-XPO5-20-GORE | 20 (40 μL) | 200 μL |
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| LRP1-XPO5-20-GOOR | 20 (40 μL) | 200 μL |
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| LRP1-XPO5-20-GOGO | 20 (40 μL) | 200 μL |
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| LRP1-XPO5-20-GOGR | 20 (40 μL) | 200 μL |
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| LRP1-XPO5-20-GOAQ | 20 (40 μL) | 200 μL |
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| LRP1-XPO5-20-GRRE | 20 (40 μL) | 200 μL |
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| LRP1-XPO5-20-GROR | 20 (40 μL) | 200 μL |
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| LRP1-XPO5-20-GRGO | 20 (40 μL) | 200 μL |
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| LRP1-XPO5-20-GRGR | 20 (40 μL) | 200 μL |
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| LRP1-XPO5-20-GRAQ | 20 (40 μL) | 200 μL |
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| LRP1-XPO5-20-AQRE | 20 (40 μL) | 200 μL |
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| LRP1-XPO5-20-AQOR | 20 (40 μL) | 200 μL |
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| LRP1-XPO5-20-AQGO | 20 (40 μL) | 200 μL |
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| LRP1-XPO5-20-AQGR | 20 (40 μL) | 200 μL |
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| LRP1-XPO5-20-AQAQ | 20 (40 μL) | 200 μL |
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LRP1 Gene Summary
This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]
Gene Name: LDL Receptor Related Protein 1
Chromosome: CHR12: 57522281 -57607125
Locus: 12q13.3
XPO5 Gene Summary
This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011]
Gene Name: Exportin 5
Chromosome: CHR6: 43490067 -43543812
Locus: 6p21.1
Gene Diseases
The LRP1 XPO5 Fusion has been associated with the following diseases:
| Disease Name |
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| Glioblastoma Multiforme |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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