LRP1-SLC39A5 Fusion FISH Probe
The LRP1-SLC39A5 Fusion FISH Probe is used to confirm a fusion of the LRP1 and SLC39A5 genes. The fusion of the LRP1 and SLC39A5 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LRP1-SLC39A5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LRP1-SLC39A5-20-RERE | 20 (40 μL) | 200 μL |
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| LRP1-SLC39A5-20-REOR | 20 (40 μL) | 200 μL |
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| LRP1-SLC39A5-20-REGO | 20 (40 μL) | 200 μL |
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| LRP1-SLC39A5-20-REGR | 20 (40 μL) | 200 μL |
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| LRP1-SLC39A5-20-REAQ | 20 (40 μL) | 200 μL |
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| LRP1-SLC39A5-20-ORRE | 20 (40 μL) | 200 μL |
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| LRP1-SLC39A5-20-OROR | 20 (40 μL) | 200 μL |
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| LRP1-SLC39A5-20-ORGO | 20 (40 μL) | 200 μL |
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| LRP1-SLC39A5-20-ORAQ | 20 (40 μL) | 200 μL |
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| LRP1-SLC39A5-20-GORE | 20 (40 μL) | 200 μL |
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| LRP1-SLC39A5-20-GOOR | 20 (40 μL) | 200 μL |
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| LRP1-SLC39A5-20-GOGO | 20 (40 μL) | 200 μL |
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| LRP1-SLC39A5-20-GOGR | 20 (40 μL) | 200 μL |
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| LRP1-SLC39A5-20-GOAQ | 20 (40 μL) | 200 μL |
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| LRP1-SLC39A5-20-GRRE | 20 (40 μL) | 200 μL |
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| LRP1-SLC39A5-20-GROR | 20 (40 μL) | 200 μL |
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| LRP1-SLC39A5-20-GRGO | 20 (40 μL) | 200 μL |
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| LRP1-SLC39A5-20-GRGR | 20 (40 μL) | 200 μL |
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| LRP1-SLC39A5-20-GRAQ | 20 (40 μL) | 200 μL |
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| LRP1-SLC39A5-20-AQRE | 20 (40 μL) | 200 μL |
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| LRP1-SLC39A5-20-AQOR | 20 (40 μL) | 200 μL |
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| LRP1-SLC39A5-20-AQGO | 20 (40 μL) | 200 μL |
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| LRP1-SLC39A5-20-AQGR | 20 (40 μL) | 200 μL |
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| LRP1-SLC39A5-20-AQAQ | 20 (40 μL) | 200 μL |
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LRP1 Gene Summary
This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]
Gene Name: LDL Receptor Related Protein 1
Chromosome: CHR12: 57522281 -57607125
Locus: 12q13.3
SLC39A5 Gene Summary
The protein encoded by this gene belongs to the ZIP family of zinc transporters that transport zinc into cells from outside, and play a crucial role in controlling intracellular zinc levels. Zinc is an essential cofactor for many enzymes and proteins involved in gene transcription, growth, development and differentiation. Mutations in this gene have been associated with autosomal dominant high myopia (MYP24). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
Gene Name: Solute Carrier Family 39 Member 5
Chromosome: CHR12: 56623819 -56631629
Locus: 12q13.3
Gene Diseases
The LRP1 SLC39A5 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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