LRP1-KLK3 Fusion FISH Probe
The LRP1-KLK3 Fusion FISH Probe is used to confirm a fusion of the LRP1 and KLK3 genes. The fusion of the LRP1 and KLK3 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LRP1-KLK3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LRP1-KLK3-20-RERE | 20 (40 μL) | 200 μL |
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| LRP1-KLK3-20-REOR | 20 (40 μL) | 200 μL |
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| LRP1-KLK3-20-REGO | 20 (40 μL) | 200 μL |
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| LRP1-KLK3-20-REGR | 20 (40 μL) | 200 μL |
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| LRP1-KLK3-20-REAQ | 20 (40 μL) | 200 μL |
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| LRP1-KLK3-20-ORRE | 20 (40 μL) | 200 μL |
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| LRP1-KLK3-20-OROR | 20 (40 μL) | 200 μL |
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| LRP1-KLK3-20-ORGO | 20 (40 μL) | 200 μL |
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| LRP1-KLK3-20-ORAQ | 20 (40 μL) | 200 μL |
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| LRP1-KLK3-20-GORE | 20 (40 μL) | 200 μL |
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| LRP1-KLK3-20-GOOR | 20 (40 μL) | 200 μL |
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| LRP1-KLK3-20-GOGO | 20 (40 μL) | 200 μL |
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| LRP1-KLK3-20-GOGR | 20 (40 μL) | 200 μL |
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| LRP1-KLK3-20-GOAQ | 20 (40 μL) | 200 μL |
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| LRP1-KLK3-20-GRRE | 20 (40 μL) | 200 μL |
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| LRP1-KLK3-20-GROR | 20 (40 μL) | 200 μL |
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| LRP1-KLK3-20-GRGO | 20 (40 μL) | 200 μL |
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| LRP1-KLK3-20-GRGR | 20 (40 μL) | 200 μL |
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| LRP1-KLK3-20-GRAQ | 20 (40 μL) | 200 μL |
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| LRP1-KLK3-20-AQRE | 20 (40 μL) | 200 μL |
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| LRP1-KLK3-20-AQOR | 20 (40 μL) | 200 μL |
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| LRP1-KLK3-20-AQGO | 20 (40 μL) | 200 μL |
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| LRP1-KLK3-20-AQGR | 20 (40 μL) | 200 μL |
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| LRP1-KLK3-20-AQAQ | 20 (40 μL) | 200 μL |
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KLK3 Gene Summary
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Kallikrein Related Peptidase 3
Chromosome: CHR19: 51358170 -51364020
Locus: 19q13.33
LRP1 Gene Summary
This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]
Gene Name: LDL Receptor Related Protein 1
Chromosome: CHR12: 57522281 -57607125
Locus: 12q13.3
Gene Diseases
The LRP1 KLK3 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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